Skip to main content

General Concepts: Stroke Systems of Care

  • Chapter
Ischemic Stroke Therapeutics

Abstract

The continuum of stroke care begins with the onset of symptoms and recognition in the field, to the discharge of the patient into the community. The ideal care of the stroke patient as he or she moves through this continuum includes coordination of systems that are designed to provide care at each step, including multiple disciplines, providers, and settings. Systems of care have been developed for the pre-hospital and inpatient portion of the continuum, but post-acute care for stroke patients is still very fragmented. The purpose of this chapter is to provide an overview of the evidence supporting the use of systems of care, and to identify the existing gaps where evidence, guidelines, and ultimately policies are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

EMS:

Emergency medical services

CMS:

Centers for Medicare and Medicaid Services

AHA:

American Heart Association

GWTG-Stroke:

Get With The Guidelines-Stroke

tPA:

Tissue plasminogen activator

DTN:

Door to needle

ESD:

Early supported discharge

IRF:

Inpatient rehabilitation facility

SNF:

Skilled nursing facility

References

  1. Morris DL, Rosamond W, Madden K, Schultz C, Hamilton S. Prehospital and emergency department delays after acute stroke: the Genentech Stroke Presentation Survey. Stroke. 2000;31(11):2585–90.

    Article  CAS  PubMed  Google Scholar 

  2. Tong D, Reeves MJ, Hernandez AF, Zhao X, Olson DM, Fonarow GC, et al. Times from symptom onset to hospital arrival in the Get With The Guidelines-Stroke program 2002 to 2009: temporal trends and implications. Stroke. 2012;43(7):1912–7.

    Article  PubMed  Google Scholar 

  3. Rossnagel K, Jungehülsing GJ, Nolte CH, Müller-Nordhorn J, Roll S, Wegscheider K, et al. Out-of-hospital delays in patients with acute stroke. Ann Emerg Med. 2004;44(5):476–83.

    Article  PubMed  Google Scholar 

  4. Rosamond WD, Gorton RA, Hinn AR, Hohenhaus SM, Morris DL. Rapid response to stroke symptoms: the Delay in Accessing Stroke Healthcare (DASH) study. Acad Emerg Med. 1998;5(1):45–51.

    Article  CAS  PubMed  Google Scholar 

  5. Morgenstern LB, Staub L, Chan W, Wein TH, Bartholomew LK, King M, et al. Improving delivery of acute stroke therapy: the TLL Temple Foundation Stroke Project. Stroke. 2002;33(1):160–6.

    Article  PubMed  Google Scholar 

  6. Hodgson C, Lindsay P, Rubini F. Can mass media influence emergency department visits for stroke? Stroke. 2007;38(7):2115–22.

    Article  PubMed  Google Scholar 

  7. Buck BH, Starkman S, Eckstein M, Kidwell CS, Haines J, Huang R, et al. Dispatcher recognition of stroke using the National Academy Medical Priority Dispatch System. Stroke. 2009;40(6):2027–30.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Ramanujam P, Guluma KZ, Castillo EM, Chacon M, Jensen MB, Patel E, et al. Accuracy of stroke recognition by emergency medical dispatchers and paramedics—San Diego experience. Prehosp Emerg Care. 2008;12(3):307–13.

    Article  PubMed  Google Scholar 

  9. Kothari RU, Pancioli A, Liu T, Brott T, Broderick J. Cincinnati prehospital stroke scale: reproducibility and validity. Ann Emerg Med. 1999;33(4):373–8.

    Article  CAS  PubMed  Google Scholar 

  10. Kidwell CS, Starkman S, Eckstein M, Weems K, Saver JL. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke. 2000;31(1):71–6.

    Article  CAS  PubMed  Google Scholar 

  11. Bray JE, Martin J, Cooper G, Barger B, Bernard S, Bladin C. Paramedic identification of stroke: community validation of the Melbourne Ambulance Stroke Screen. Cerebrovasc Dis. 2005;20(1):28–33.

    Article  PubMed  Google Scholar 

  12. Lahr MMH, Luijckx G-J, Vroomen PCAJ, van der Zee D-J, Buskens E. Proportion of patients treated with thrombolysis in a centralized versus a decentralized acute stroke care setting. Stroke. 2012;43(5):1336–40.

    Article  CAS  PubMed  Google Scholar 

  13. Prabhakaran S, O’Neill K, Stein-Spencer L, Walter J, Alberts MJ. Prehospital triage to primary stroke centers and rate of stroke thrombolysis. JAMA Neurol. 2013;70(9):1126–32.

    Article  PubMed  Google Scholar 

  14. Gladstone DJ, Rodan LH, Sahlas DJ, Lee L, Murray BJ, Ween JE, et al. A citywide prehospital protocol increases access to stroke thrombolysis in Toronto. Stroke. 2009;40(12):3841–4.

    Article  CAS  PubMed  Google Scholar 

  15. Higashida R, Alberts MJ, Alexander DN, Crocco TJ, Demaerschalk BM, Derdeyn CP, et al. Interactions within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association. Stroke. 2013;44(10):2961–84.

    Article  PubMed  Google Scholar 

  16. Baldereschi M, Piccardi B, Di Carlo A, Lucente G, Guidetti D, Consoli D, et al. Relevance of prehospital stroke code activation for acute treatment measures in stroke care: a review. Cerebrovasc Dis. 2012;34(3):182–90.

    Article  PubMed  Google Scholar 

  17. Kim SK, Lee SY, Bae HJ, Lee YS, Kim SY, Kang MJ, et al. Pre-hospital notification reduced the door-to-needle time for iv t-PA in acute ischaemic stroke. Eur J Neurol. 2009;16(12):1331–5.

    Article  CAS  PubMed  Google Scholar 

  18. Lin CB, Peterson ED, Smith EE, Saver JL, Liang L, Xian Y, et al. Emergency medical service hospital prenotification is associated with improved evaluation and treatment of acute ischemic stroke. Circ Cardiovasc Qual Outcomes. 2012;5(4):514–22.

    Article  PubMed  Google Scholar 

  19. McKinney JS, Mylavarapu K, Lane J, Roberts V, Ohman-Strickland P, Merlin MA. Hospital prenotification of stroke patients by emergency medical services improves stroke time targets. J Stroke Cerebrovasc Dis. 2013;22(2):113–8.

    Article  PubMed  Google Scholar 

  20. Patel MD, Rose KM, O’Brien EC, Rosamond WD. Prehospital notification by emergency medical services reduces delays in stroke evaluation: findings from the North Carolina stroke care collaborative. Stroke. 2011;42(8):2263–8.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Kostopoulos P, Walter S, Haass A, Papanagiotou P, Roth C, Yilmaz U, et al. Mobile stroke unit for diagnosis-based triage of persons with suspected stroke. Neurology. 2012;78(23):1849–52.

    Article  CAS  PubMed  Google Scholar 

  22. Liman TG, Winter B, Waldschmidt C, Zerbe N, Hufnagl P, Audebert HJ, et al. Telestroke ambulances in prehospital stroke management: concept and pilot feasibility study. Stroke. 2012;43(8):2086–90.

    Article  PubMed  Google Scholar 

  23. Bergrath S, Rörtgen D, Rossaint R, Beckers SK, Fischermann H, Brokmann JC, et al. Technical and organisational feasibility of a multifunctional telemedicine system in an emergency medical service—an observational study. J Telemed Telecare. 2011;17(7):371–7.

    Article  PubMed  Google Scholar 

  24. Fang M, Cutler D, Rosen A. Trends in thrombolytic use for ischemic stroke in the United States. J Hosp Med. 2010;5:406–9.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Lanska DJ, Kryscio R. Geographic distribution of hospitalization rates, case fatality, and mortality from stroke in the United States. Neurology. 1994;44(8):1541–50.

    Article  CAS  PubMed  Google Scholar 

  26. Pickle LW, Mungiole M, Gillum RF. Geographic variation in stroke mortality in blacks and whites in the United States. Stroke. 1997;28(8):1639–47.

    Article  CAS  PubMed  Google Scholar 

  27. Schwamm L, Reeves M, Pan W, Smith E, Frankel M, Olson D, et al. Race/ethnicity, quality of care, and outcomes in ischemic stroke. Circulation. 2010;121:1492–501.

    Article  PubMed  Google Scholar 

  28. Alberts MJ, Hademenos G, Latchaw RE, Jagoda A, Marler JR, Mayberg MR, et al. Recommendations for the establishment of primary stroke centers. JAMA. 2000;283:3102–9.

    Article  CAS  PubMed  Google Scholar 

  29. Alberts MJ, Latchaw RE, Selman WR, Shephard T, Hadley MN, Brass LM, et al. Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke. 2005;36(7):1597–616.

    Article  PubMed  Google Scholar 

  30. Jauch EC, Saver JL, Adams Jr HP, Bruno A, Connors JJB, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870–947.

    Article  PubMed  Google Scholar 

  31. Fonarow GC, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Grau-Sepulveda MV, et al. Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes. Circulation. 2011;123(7):750–8.

    Article  CAS  PubMed  Google Scholar 

  32. Fonarow GC, Smith EE, Saver JL, Reeves MJ, Hernandez AF, Peterson ED, et al. Improving door-to-needle times in acute ischemic stroke: the design and rationale for the American Heart Association/American Stroke Association’s Target: stroke initiative. Stroke. 2011;42(10):2983–9.

    Article  PubMed  Google Scholar 

  33. Ford AL, Williams JA, Spencer M, McCammon C, Khoury N, Sampson TR, et al. Reducing door-to-needle times using Toyota’s lean manufacturing principles and value stream analysis. Stroke. 2012;43(12):3395–8.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Meretoja A, Strbian D, Mustanoja S, Tatlisumak T, Lindsberg PJ, Kaste M. Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology. 2012;79(4):306–13.

    Article  PubMed  Google Scholar 

  35. Lindsberg PJ, Häppölä O, Kallela M, Valanne L, Kuisma M, Kaste M. Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatment. Neurology. 2006;67(2):334–6.

    Article  CAS  PubMed  Google Scholar 

  36. Alberts MJ, Latchaw RE, Jagoda A, Wechsler LR, Crocco T, George MG, et al. Revised and updated recommendations for the establishment of primary stroke centers: a summary statement from the Brain Attack Coalition. Stroke. 2011;42(9):2651–65.

    Article  PubMed  Google Scholar 

  37. Lattimore SU, Chalela J, Davis L, DeGraba T, Ezzeddine M, Haymore J, et al. Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003;34(6):e55–7.

    Article  PubMed  Google Scholar 

  38. Xian Y, Holloway RG, Chan PS, et al. Association between stroke center hospitalization for acute ischemic stroke and mortality. JAMA. 2011;305(4):373–80.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Meretoja A, Roine RO, Kaste M, Linna M, Roine S, Juntunen M, et al. Effectiveness of primary and comprehensive stroke centers: PERFECT Stroke: a nationwide observational study from Finland. Stroke. 2010;41(6):1102–7.

    Article  PubMed  Google Scholar 

  40. McKinney JS, Deng Y, Kasner SE, Kostis JB. Comprehensive stroke centers overcome the weekend versus weekday gap in stroke treatment and mortality. Stroke. 2011;42(9):2403–9.

    Article  PubMed  Google Scholar 

  41. Rymer MM, Armstrong EP, Meredith NR, Pham SV, Thorpe K, Kruzikas DT. Analysis of the costs and payments of a coordinated stroke center and regional stroke network. Stroke. 2013;44(8):2254–9.

    Article  PubMed  Google Scholar 

  42. Fagan SC, Morgenstern LB, Petitta A, Ward RE, Tilley BC, Marler JR, et al. Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke. NINDS rt-PA Stroke Study Group. Neurology. 1998;50(4):883–90.

    Article  CAS  PubMed  Google Scholar 

  43. Leifer D, Bravata DM, Connors JJ, Hinchey JA, Jauch EC, Johnston SC, et al. Metrics for measuring quality of care in comprehensive stroke centers: detailed follow-up to brain attack coalition comprehensive stroke center recommendations a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(3):849–77.

    Article  PubMed  Google Scholar 

  44. Katzan IL, Spertus J, Bettger JP, Bravata DM, Reeves MJ, Smith EE, et al. Risk adjustment of ischemic stroke outcomes for comparing hospital performance: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(3):918–44.

    Article  PubMed  Google Scholar 

  45. Medicare Payment Advisory Commission. Report to the Congress: medicare and the health care delivery system. Washington, DC: MedPAC; 2013.

    Google Scholar 

  46. Borah BJ, Rock MG, Wood DL, Roellinger DL, Johnson MG, Naessens JM. Association between value-based purchasing score and hospital characteristics. BMC Health Serv Res. 2012;12:464.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Sandel ME, Jette AM, Appelman J, Terdiman J, TeSelle M, Delmonico RL, et al. Designing and implementing a system for tracking functional status after stroke: a feasibility study. PM&R [Internet]. [cited 2013 Mar 24]. http://www.sciencedirect.com/science/article/pii/S1934148212010465.

  48. Olson DM, Cox M, Pan W, Sacco RL, Fonarow GC, Zorowitz R, et al. Death and rehospitalization after transient ischemic attack or acute ischemic stroke: one-year outcomes from the adherence evaluation of acute ischemic stroke–longitudinal registry. J Stroke Cerebrovasc Dis. 2013;22(7):e181–8.

    Article  PubMed  Google Scholar 

  49. Buntin MB. Access to postacute rehabilitation. Arch Phys Med Rehabil. 2007;88(11):1488–93.

    Article  PubMed  Google Scholar 

  50. Chan L, Sandel ME, Jette AM, Appelman J, Brandt DE, Cheng P, et al. Does postacute care site matter? A longitudinal study assessing functional recovery after a stroke. Arch Phys Med Rehabil. 2013;94(4):622–9.

    Article  PubMed Central  PubMed  Google Scholar 

  51. Fonarow G, Smith E, Reeves M, Pan W, Olson D, Hernandez A, et al. Hospital-level variation in mortality and rehospitalization for Medicare beneficiaries with acute ischemic stroke. Stroke. 2011;42:159–66.

    Article  PubMed  Google Scholar 

  52. Prvu Bettger J, Alexander KP, Dolor RJ, Olson DM, Kendrick AS, Wing L, et al. Transitional care after hospitalization for acute stroke or myocardial infarction: a systematic review. Ann Intern Med. 2012;157(6):407–16.

    Article  PubMed  Google Scholar 

  53. Fisher RJ, Gaynor C, Kerr M, Langhorne P, Anderson C, Bautz-Holter E, et al. A consensus on stroke early supported discharge. Stroke. 2011;42(5):1392–7.

    Article  PubMed  Google Scholar 

  54. Fearon P, Langhorne P, Early Supported Discharge Trialists. Services for reducing duration of hospital care for acute stroke patients. Cochrane Database Syst Rev. 2012;9:CD000443.

    Google Scholar 

  55. Krueger H, Lindsay P, Cote R, Kapral MK, Kaczorowski J, Hill MD. Cost avoidance associated with optimal stroke care in Canada. Stroke. 2012;43(8):2198–206.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amy K. Guzik M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Guzik, A.K., Bushnell, C.D. (2016). General Concepts: Stroke Systems of Care. In: Ovbiagele, B. (eds) Ischemic Stroke Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-319-17750-2_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-17750-2_27

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17749-6

  • Online ISBN: 978-3-319-17750-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics