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Molecular Mechanisms of IgE Class Switch Recombination

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Book cover IgE Antibodies: Generation and Function

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 388))

Abstract

Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon—assembled from component gene segments via V(D)J recombination during early B cell development—upstream of a set of IgH constant region CH exons. Upon activation by antigen in peripheral lymphoid organs, B cells can undergo IgH class switch recombination (CSR), a process in which the initially expressed IgH μ constant region exons (Cμ) are deleted and replaced by one of several sets of downstream CH exons (e.g., Cγ, Cε, and Cα). Activation of the IL-4 receptor on B cells, together with other signals, can lead to the replacement of Cμ with Cε resulting in CSR to IgE through a series of molecular events involving irreversible remodeling of the IgH locus. Here, we discuss the molecular mechanisms of CSR and the unique features surrounding the generation of IgE-producing B cells.

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Acknowledgements

D.R.W. is supported by NIH grants AI089972 and AI113217, by the Mucosal Immunology Studies Team, and holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund.

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  1. Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Pei Tong & Duane R. Wesemann

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Correspondence to Duane R. Wesemann .

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  1. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

  2. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Maria A. Curotto de Lafaille

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Tong, P., Wesemann, D.R. (2015). Molecular Mechanisms of IgE Class Switch Recombination. In: Lafaille, J., Curotto de Lafaille, M. (eds) IgE Antibodies: Generation and Function. Current Topics in Microbiology and Immunology, vol 388. Springer, Cham. https://doi.org/10.1007/978-3-319-13725-4_2

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