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Abstract

The application of cardiovascular CT imaging toward the detection, characterization, and prognostication of coronary artery disease (CAD) is one of the most rapidly evolving and exciting aspects of cardiovascular medicine. Coronary computed tomographic angiography (CCTA) has revolutionized the diagnosis and management of coronary artery disease by providing new methods for noninvasive imaging of coronary arteries. Coronary arterial calcification of plaques, plaque progression, stenosis characterization, plaque analysis, and appropriate use criteria will be presented below.

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References

  1. Margolis JR, et al. The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology. 1980;137(3):609–16.

    Article  CAS  PubMed  Google Scholar 

  2. Kondos GT, et al. Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation. 2003;107(20):2571–6.

    Article  PubMed  Google Scholar 

  3. O’Rourke RA, et al. American College of Cardiology/American Heart Association Expert Consensus document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease. Circulation. 2000;102(1):126–40.

    Article  PubMed  Google Scholar 

  4. Budoff MJ, et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol. 2007;49(18):1860–70.

    Article  PubMed  Google Scholar 

  5. Detrano R, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358(13):1336–45.

    Article  CAS  PubMed  Google Scholar 

  6. Polonsky TS, et al. Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA. 2010;303(16):1610–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Arad Y, et al. Treatment of asymptomatic adults with elevated coronary calcium scores with atorvastatin, vitamin C, and vitamin E: the St. Francis Heart Study randomized clinical trial. J Am Coll Cardiol. 2005;46(1):166–72.

    Article  CAS  PubMed  Google Scholar 

  8. Kroft LJ, de Roos A, Geleijns J. Artifacts in ECG-synchronized MDCT coronary angiography. AJR Am J Roentgenol. 2007;189(3):581–91.

    Article  CAS  PubMed  Google Scholar 

  9. Budoff MJ, et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol. 2008;52(21):1724–32.

    Article  PubMed  Google Scholar 

  10. Voros S, et al. Coronary atherosclerosis imaging by coronary CT angiography: current status, correlation with intravascular interrogation and meta-analysis. JACC Cardiovasc Imaging. 2011;4(5):537–48.

    Article  PubMed  Google Scholar 

  11. Ehara S, et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation. 2004;110(22):3424–9.

    Article  PubMed  Google Scholar 

  12. Virmani R, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–75.

    Article  CAS  PubMed  Google Scholar 

  13. Glagov S, et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316(22):1371–5.

    Article  CAS  PubMed  Google Scholar 

  14. Motoyama S, et al. Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. J Am Coll Cardiol. 2009;54(1):49–57.

    Article  PubMed  Google Scholar 

  15. Raff GL, et al. Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol. 2005;46(3):552–7.

    Article  PubMed  Google Scholar 

  16. Raff GL, et al. SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography. J Cardiovasc Comput Tomogr. 2009;3(2):122–36.

    Article  PubMed  Google Scholar 

  17. Rispler S, et al. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol. 2007;49(10):1059–67.

    Article  PubMed  Google Scholar 

  18. George RT, et al. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: the CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study. AJR Am J Roentgenol. 2011;197(4):829–37.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Achenbach S, et al. Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound. Circulation. 2004;109(1):14–7.

    Article  PubMed  Google Scholar 

  20. Schoenhagen P, et al. Non-invasive assessment of plaque morphology and remodeling in mildly stenotic coronary segments: comparison of 16-slice computed tomography and intravascular ultrasound. Coron Artery Dis. 2003;14(6):459–62.

    Article  PubMed  Google Scholar 

  21. Hoffmann U, et al. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol. 2006;47(8):1655–62.

    Article  PubMed  Google Scholar 

  22. Schmermund A, Mohlenkamp S, Schlosser T, Raimund E. Coronary angiography after revascularization. In: Budoff MJ, Shinbane JS, editors. Cardiac CT imaging: diagnosis of cardiovascular disease. London: Springer; 2006. p. 135–45.

    Chapter  Google Scholar 

  23. Jen-Sho Chen J, White C. CT angiography for coronary artery bypass graft surgery. Appl Radiol. 2008;37:10–8.

    Google Scholar 

  24. Martuscelli E. Coronary artery bypass grafts. In: Dewey M, editor. Cardiac CT. Berlin: Springer; 2011. p. 171–8.

    Chapter  Google Scholar 

  25. Anders K. Coronary artery stents. In: Dewey M, editor. Cardiac CT. Berlin: Springer; 2011. p. 179–90.

    Google Scholar 

  26. Mahnken A. CT imaging of coronary stents: past, present, and future. ISRN Cardiol. 2012;2012:1–12.

    Article  Google Scholar 

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Musani, M.H., Vainrib, A., Gupta, R., Poon, M. (2015). Coronary Artery Disease Evaluation Using Cardiac CTA. In: Clinical Pearls in Diagnostic Cardiac Computed Tomographic Angiography. Springer, Cham. https://doi.org/10.1007/978-3-319-08168-7_4

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  • DOI: https://doi.org/10.1007/978-3-319-08168-7_4

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08167-0

  • Online ISBN: 978-3-319-08168-7

  • eBook Packages: MedicineMedicine (R0)

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