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Bacterial resistance to antibiotics: The role of biofilms

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Summary

Bacteria adhere to natural and synthetic, medically important surfaces within an extracellular polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced antibiotic resistance of biofilm bacteria, relative to floating (planktonic) bacteria, encourages the establishment of chronic bacterial infections. Resistance mechanisms include the hinderance of antibiotic diffusion by the glycocalyx, the physiology of the bacteria and the environment conditions of the niche in which the biofilm resides.

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  1. Biofilm Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, T2N 1N4

    Brian D. Hoyle & J. William Costerton

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  1. Brian D. Hoyle
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  2. J. William Costerton
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  1. Basel, Switzerland

    Ernst Jucker

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© 1991 Birkhäuser Verlag Basel

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Hoyle, B.D., Costerton, J.W. (1991). Bacterial resistance to antibiotics: The role of biofilms. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 37. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7139-6_2

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  • DOI: https://doi.org/10.1007/978-3-0348-7139-6_2

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