Abstract
It has been ten years since a beta-adrenergic receptor (beta-adrenoceptor) blocking agent was introduced into clinical medicine. Pronethalol first, then propranolol was used successfully to treat angina pectoris [1]. Other effective uses for propranolol were quickly found: hypertension [2], cardiac arrhythmias [3], hyperkinetic circulatory syndrome, obstructive cardiomyopathy, thyrotoxicosis, migraine, anxiety and essential tremor. More beta-blockers were discovered and developed. At this writing only propranolol is approved by the Federal Food and Drug Administration (FDA) for use in the United States, and then only for arrhythmias, obstructive cardiomyopathy and angina. In the rest of the world eight or nine others are in common use.
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Ahlquist, R.P. (1976). Adrenergic Beta-Blocking Agents. In: Jucker, E. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques, vol 20. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7094-8_2
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