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Molecular mechanisms and physiology of disease pp 63–79Cite as

Role of Epigenetics in Neural Differentiation: Implications for Health and Disease

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Abstract

Neural differentiation is a complex process that requires highly accurate spatial and temporal regulation by extracellular and intracellular programs. Epigenetic mechanisms, such as DNA methylation, covalent histone posttranscriptional modifications, chromatin organization, and noncoding regulatory RNA, are key regulators of pluripotency maintenance and differentiation. The misregulation of these mechanisms could lead to neurological diseases and cancer.

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Authors and Affiliations

  1. Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain

    Estela G. Toraño Ph.D., Agustin F. Fernandez Ph.D., Rocio G. Urdinguio Ph.D. & Mario F. Fraga Ph.D.

  2. Department of Immunology and Oncology, National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid, 28049, Spain

    Mario F. Fraga Ph.D.

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Correspondence to Mario F. Fraga Ph.D. .

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  1. Department of Surgery Molecular cardiology and Angiogenesis, University of Connecticut School of Medicine, Farmington, Connecticut, USA

    Nilanjana Maulik

  2. Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

    Tom Karagiannis

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© 2014 Springer Science+Business Media New York

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Toraño, E.G., Fernandez, A.F., Urdinguio, R.G., Fraga, M.F. (2014). Role of Epigenetics in Neural Differentiation: Implications for Health and Disease. In: Maulik, N., Karagiannis, T. (eds) Molecular mechanisms and physiology of disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0706-9_2

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