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Aging and Heart Failure pp 135–146Cite as

Biomarkers and Optimal Management of Heart Failure in the Aging Population

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Abstract

The incidence of heart failure (HF) increases with advancing age with a lifetime risk for the diagnosis of 20 %. There are physiological changes that predispose the elderly to developing HF and small insults may rapidly precipitate decompensation of symptoms. There are special challenges in diagnosing and managing elderly patients with HF, challenges that biomarkers can help mitigate. Natriuretic peptides such as B-type natriuretic peptide and N-terminal proBNP are established biomarkers that have been proven to accurately diagnose and prognosticate HF. There are additional promising novel biomarkers that may be of use.

Relationship with industry: Dr. Januzzi reports the following disclosures: (1) Roche Diagnostics: research grants, consultancy; (2) Siemens Diagnostics: research grants; (3) Critical Diagnostics: research grants, consultancy; (4) BRAHMS: research grants. (5) Singulex: research grants Dr. Gaggin does not have disclosures.

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Abbreviations

ACC:

American College of Cardiology

ACE:

Angiotensin converting enzyme

ADHERE:

Acute Decompensated Heart Failure National Registry

AHA:

American Heart Association

ANP:

Atrial natriuretic peptide

ARB:

Angiotensin II receptor blockers

BACH:

Biomarkers in Acute Heart Failure

BATTLESCARRED:

The NT-proBNP-Assisted Treatment to Lessen Serial Cardiac Readmissions and Death

BNP:

B-type natriuretic peptide

CHS:

Cardiovascular Health Study

GDF:

Growth differentiation factor

HF:

Heart failure

HFpEF:

Heart failure with preserved ejection fraction

hsTnT:

Highly sensitive troponin T

LVSD:

Left ventricular systolic dysfunction

MR-proADM:

Mid-regional pro adrenomedullin

MR-proANP:

Mid-regional pro atrial natriuretic peptide

NP:

Natriuretic peptide(s)

NT-proBNP:

Amino-terminal B-type natriuretic peptide

PCWP:

Pulmonary capillary wedge pressure

PRIDE:

ProBNP Investigation of Dyspnea in the Emergency Department

PROTECT:

ProBNP Outpatient Tailored Chronic Heart Failure Therapy

REDHOT:

Rapid Emergency Department Heart Failure Outpatient Trial

sST2:

Soluble ST2

TIME-CHF:

Trial of Intensified versus Standard Medical therapy in Elderly Patients with Congestive HF

Val-HeFT:

Valsartan Heart Failure

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Author information

Authors and Affiliations

  1. Cardiology Division, Department of Medicine, Massachusetts General Hospital, 55 Fruit St. Yawkey 5B, Boston, MA, 02114, USA

    Hanna K. Gaggin MD, MPH

  2. Cardiology Division, Department of Medicine, Boston, MA, USA

    James L. Januzzi Jr. MD

Authors
  1. Hanna K. Gaggin MD, MPH
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  2. James L. Januzzi Jr. MD
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Correspondence to Hanna K. Gaggin MD, MPH .

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Editors and Affiliations

  1. Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

Additional information

Funding: Dr. Gaggin is supported in part by the Clark Fund for Cardiac Research Innovation. Dr. Januzzi is supported in part by the Roman W. DeSanctis Clinical Scholar Endowment.

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Gaggin, H.K., Januzzi, J.L. (2014). Biomarkers and Optimal Management of Heart Failure in the Aging Population. In: Jugdutt, B. (eds) Aging and Heart Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0268-2_10

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