Abstract
There are three major mechanisms whereby bacteria initially susceptible to an antimicrobial agent may acquire the ability to resist the effects of this agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme. The relative importance of each of these mechanisms varies depending upon the organism involved, the antimicrobial agent, and the location of the target of the antimicrobial agent within the bacterial cell (Table 1).
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References
H. Nikaido. Bacterial resistance to antibiotics as a function of outer membrane permeability. J Antimicrob Chemother. 22 (Suppl A): 17 (1988).
C.C. Sanders, and W. E. Sanders, Jr. 13-lactam resistance in gram-negative bacteria: global trends and clinical impact. Clin Infect Dis. 15: 824 (1992).
J. D. Hayes, and C. R. Wolf. Molecular mechanisms of drug resistance. Biochem J. 272: 281 (1990).
I. Chopra. Efflux-based antibiotic resistance mechanisms: the evidence for increasing prevalence. J Antimicrob Chemother. 30: 737 (1992).
G. A. Jacoby, and G. L. Archer. New mechanisms of bacterial resistance to antimicrobial agents. New Engl J Med. 324: 601 (1991).
H. F. Chambers. Methicillin-resistant staphylococci. Clin Microbiol Rev. 1: 173 (1988).
N. H. Georgopapadakou. Penicillin-binding proteins and bacterial resistance to (3lactams. Antimicrob. Agents Chemother. 37: 2045 (1993).
D. M. Shlaes, A. Bouvet, C. Devine, J. H. Shlaes, S. al-Obeid,and R. Williamson. Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256. Antimicrob Agents Chemother. 33: 198 (1989).
J. S. Wolfson, and D. C. Hooper. Fluoroquinolone antimicrobial agents. Clin Microbiol Rev. 2: 378 (1989).
K. Bush. Characterization of ß-lactamases. Antimicrob Agents Chemother. 33: 259 (1989).
J. E. Davies. Aminoglycoside-aminocyclitol antibiotics and their modifying enzymes, in “Antibiotics in Laboratory Medicine, 2nd ed.,” V. Lorian, ed., Williams Wilkins, Baltimore (1986)
B. E. Murray. The life and times of the enterococcus. Clin Microbiol Rev. 3: 46 (1990).
C. C. Sanders. ß-lactamases of gram-negative bacteria: new challenges for new drugs. Clin Infect Dis. 14: 1089 (1992).
C. C. Sanders. Chromosomal cephalosporinases responsible for multiple resistance to newer ß-lactam antibiotics. Annu Rev Microbiol. 41: 573 (1987).
G. A. Jacoby, and A. A. Medeiros. More extended-spectrum ß-lactamases. Antimicrob Agents Chemother. 35: 1697 (1991).
C. J. Thomson, and S.G.B. Amyes. Selection of variants of the TEM-1 ß-lactamase, encoded by a plasmid of clinical origin, with increased resistance to ß-lactamase inhibitors. J Antimicrob Chemother. 31: 655 (1993).
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© 1995 Springer Science+Business Media New York
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Sanders, C.C., Sanders, W.E. (1995). Resistance to Antibacterial Agents. In: Jungkind, D.L., Mortensen, J.E., Fraimow, H.S., Calandra, G.B. (eds) Antimicrobial Resistance. Advances in Experimental Medicine and Biology, vol 390. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9203-4_2
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DOI: https://doi.org/10.1007/978-1-4757-9203-4_2
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