Abstract
Ether lipids have several biological functions as important components of mammalian cells. Considerable interest has recently focussed on the “platelet activating factor” (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), which seems to be of pathogenic importance in the mediation of allergic and inflammatory reactions. A number of analogs of PAF whithout platelet aggregating activity are cytotoxic for a variety of cell types3. Racemic 1-octadecyl-2-methyl-glycero-3-phosphocholine (Et-18-0CH3; INN: Edelfosine) was the prototype in this class of new anti-cancer agents to undergo preclinical evaluation.
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© 1990 Springer Science+Business Media New York
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Schumacher, W., Stekar, J., Hilgard, P., Engel, J., Eibl, H., Unger, C. (1990). Hexadecylphosphocholine (D-18506): A New Phospholipid with Highly Selective Antitumor Activity. In: Hanin, I., Pepeu, G. (eds) Phospholipids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1364-0_27
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DOI: https://doi.org/10.1007/978-1-4757-1364-0_27
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