Abstract
At the turn of the century it was widely accepted that in a fluid system, such as the living cell, ions must be the carriers of electric currents. Since the uneven distribution of Na+ and K+ ions between the interior of cells and their outer environment was already known, Overton(63) proposed, on the basis of simple experiments, that during electrical activity Na+ ions move into the cell interior and an equivalent amount of K+ ions flow to the outside. It is common knowledge that Overton’s assumption was borne out when, after World War II, radioactive ions became available and made it possible to measure ion movements during rest and during activity. But the fundamental question for understanding these processes is that of the control of these ion movements. It was postulated at the turn of the century that the cell membranes surrounding nerve and muscle fibers must have a special ability to change their permeability to ions during activity, although at that time cell membranes were largely a hypothetical postulate. No mechanism was considered for explaining the changes of permeability to ions.
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Nachmansohn, D. (1970). Proteins in Bioelectricity. In: Lajtha, A. (eds) Protein Metabolism of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8109-9_15
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