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Antimutagenesis and Anticarcinogenesis Mechanisms II pp 195–204Cite as

Inhibition of Tumor Promotion by DL-α-Difluoromethylornithine, A Specific Irreversible Inhibitor of Ornithine Decarboxylase

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Part of the book series: Basic Life Sciences ((BLSC,volume 52))

Abstract

Although a chemoprevention program can be targeted for intervention at any one of the steps (initiation, promotion, and progression) involved in the induction of cancer, interference with the promotion stage of carcinogenesis appears to be most appropriate and practical. The rationale behind this comes from the facts that promotion of tumor formation requires a repeated and prolonged exposure to a promoter and that tumor promotion is reversible, at least in the early stages. In contrast, initiation can be accomplished by a single exposure to a sufficiently small dose of a carcinogen, and this step is rapid and irreversible (3,36,41).

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Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin Clinical Cancer Center, 53792, Madison, Wisconsin, USA

    Ajit K. Verma

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  1. Ajit K. Verma
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Editors and Affiliations

  1. National Institute of Genetics, Mishima, Japan

    Yukiaki Kuroda

  2. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  3. United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Michael D. Waters

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© 1990 Plenum Press, New York

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Verma, A.K. (1990). Inhibition of Tumor Promotion by DL-α-Difluoromethylornithine, A Specific Irreversible Inhibitor of Ornithine Decarboxylase. In: Kuroda, Y., Shankel, D.M., Waters, M.D. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms II. Basic Life Sciences, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9561-8_16

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  • DOI: https://doi.org/10.1007/978-1-4615-9561-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9563-2

  • Online ISBN: 978-1-4615-9561-8

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