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Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials

  • Conference proceedings
  • © 2013

Overview

Editors:
  1. Thomas R. Fleming

    1. University of Washington, Seattle, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Bruce S. Weir

    1. University of Washington, Seattle, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Covers wide range of advances in clinical trials research
  • Many new techniques in the areas of biomarkers and the use of molecular and genetic bioinformatics are covered in detail
  • Includes articles by important biostatisticians working today
  • Includes supplementary material: sn.pub/extras

Part of the book series: Lecture Notes in Statistics (LNS, volume 1205)

Part of the book sub series: Lecture Notes in Statistics - Proceedings (LNSP)

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Table of contents (12 papers)

  1. Front Matter

    Pages i-viii
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  3. Biomarkers: Issues in Individualized Therapy

    1. Front Matter

      Pages 47-47
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    2. Recent Developments in the Use of Clinical Trials to Support Individualizing Therapies: A Regulatory Perspective

      • Robert T. O’Neill
      Pages 49-62

    3. Oncology Clinical Trials in the Genomic Era

      • Richard Simon, Jyothi Subramanian
      Pages 63-79

    4. Using SNPs to Characterize Genetic Effects in Clinical Trials

      • B. S. Weir
      Pages 81-91

  4. Issues in Multi-Regional Clinical Trials

    1. Front Matter

      Pages 93-93
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    2. Why Is This Subgroup Different from All Other Subgroups? Thoughts on Regional Differences in Randomized Clinical Trials

      • Janet Wittes
      Pages 95-115

  6. Special Topics

    1. Front Matter

      Pages 175-175
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    2. Designing, Monitoring, and Analyzing Group Sequential Clinical Trials Using the RCTdesign Package for R

      • Daniel L. Gillen, Scott S. Emerson
      Pages 177-208

    3. Genetic Markers in Clinical Trials

      • B. S. Weir, P. J. Heagerty
      Pages 209-245

  7. Back Matter

    Pages 247-249
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Keywords

About this book

This volume contains a selection of chapters base on papers presented at the Fourth Seattle Symposium in Biostatistics: Clinical Trials. The symposium was held in 2010 to celebrate the 40th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by David DeMets and Susan Ellenberg and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important clinical trials research, such as biomarkers, meta-analyses, sequential and adaptive clinical trials, and various genetic bioinformatic techniques. This volume will be a valuable reference for researchers and practitioners in the field of clinical trials.

Editors and Affiliations

  • University of Washington, Seattle, USA

    Thomas R. Fleming, Bruce S. Weir

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