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Experimental Hematology Today—1989 pp 58–64Cite as

Biosynthesis and Processing of the Cytoadhesins, GPIIb/IIIa and Vitronectin Receptor

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Part of the book series: Experimental Hematology Today—1989 ((HEMATOLOGY,volume 1989))

Abstract

Integrins are heterodimers comprised of non covalently associated α and β subunits (1, 2). This family has been divided into four groups of adhesion receptors, according to their β subunit. Each group is composed of glycoproteins sharing the same β subunit and different α subunits. This includes the VLA family (3), the leukocyte adhesion proteins LFA-1, Mac-1 and p 150,95 (4), the cytoadhesin family (5), and the newly identified epithelial integrin (6). The platelet GPIIb/IIIa and the vitronectin receptor (VNR) belong to the cytoadhesin family (5) and share the same β subunit, i.e. GPIIIa or VNRβ (7), according to its primary sequence (8–10) and distinct a subunits, i.e. GPIIb or VNRα (11–13).

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Authors
  1. A. Troesch
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  2. A. Duperray
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  3. R. Berthier
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  4. G. Marguerie
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Editors and Affiliations

  1. Department of Hematology, Saint-Antoine Hospital, 184, rue du Faubourg Saint-Antoine, 75571, Paris, France

    Norbert C. Gorin M.D.  & Luc Douay M.D.  & 

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© 1990 Springer-Verlag New York Inc.

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Troesch, A., Duperray, A., Berthier, R., Marguerie, G. (1990). Biosynthesis and Processing of the Cytoadhesins, GPIIb/IIIa and Vitronectin Receptor. In: Gorin, N.C., Douay, L. (eds) Experimental Hematology Today—1989. Experimental Hematology Today—1989, vol 1989. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9003-9_10

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  • DOI: https://doi.org/10.1007/978-1-4613-9003-9_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9005-3

  • Online ISBN: 978-1-4613-9003-9

  • eBook Packages: Springer Book Archive

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