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Sympathomimetic Amines in the Treatment of Shock

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Abstract

The term sympathomimetic amine was coined almost 100 years ago by Barger and Dale (1) to distinguish chemical compounds with amine structures that caused effects similar to stimulation of sympathetic nerves. Forty years later, Ahlquist (2) concluded that the action of sympathomimetic amines was mediated by activation of two distinct receptors: alpha and beta. Continuing studies have led to further subdivision of alpha- and beta-adrenoceptors into two subtypes: alpha-1 and alpha-2, and beta-1 and beta-2 (3,4).

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References

  1. Barger G, Dale H: Chemical structure and sympa-thomimetic action of amines. J Physiol 41: 19–59, 1910.

    PubMed  CAS  Google Scholar 

  2. Ahlquist RP: A study of adrenotropic receptors. Am J Physiol 153: 586–600, 1948.

    PubMed  CAS  Google Scholar 

  3. Lands AM, Arnold A, McAuliff P, Ludena FP, Brown AG, Jr: Differentiation of receptor systems activated by sympathomimetic amines. Nature 2: 597–598, 1967.

    Article  Google Scholar 

  4. Langer SZ: Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32: 337–362, 1981.

    Google Scholar 

  5. Goldberg LI: Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev 24: 1–29, 1972.

    PubMed  CAS  Google Scholar 

  6. Goldberg LI, Volkman PH, Kohli JD: A comparison of the vascular dopamine receptor with other dopamine receptors. Ann Rev Pharmacol Toxicol 18: 57–79, 1978.

    Article  CAS  Google Scholar 

  7. Goldberg LI, Kohli JD: Peripheral pre- and post-synaptic dopamine receptors: are they different from dopamine receptors in the central nervous system? Commun Psychopharmacol 3: 447–456, 1979.

    PubMed  CAS  Google Scholar 

  8. Goldberg LI, Kohli JD: Differentiation of dopamine receptors in the periphery. Kaiser C, Kebabian JW (eds): American Chemical Society Symposium Series #224 Dopamine Receptors, pp 101–113, 1983.

    Google Scholar 

  9. Braunwald E, Bloodwell RD, Goldberg LI, Morrow AG: Studies on digitalis. IV. Observations in man on the effects of digitalis preparations on the con-tractility of the nonfailing heart and on total vascular resistance. J Clin Invest 40: 52–59, 1961.

    Article  PubMed  CAS  Google Scholar 

  10. Goldberg LI, Bloodwell RD, Braunwald E, Morrow AB: The direct effects of norepinephrine, epinephrine and methoxamine on myocardial contractile force in man. Circulation 22: 1125–1132, 1960.

    PubMed  CAS  Google Scholar 

  11. Goldberg LI, Hsieh YY, Resnekov L: Newer catecholamines for treatment of heart failure and shock. An update on dopamine and a first look at dobut- amine. Prog Cardiovasc Dis 4: 327–340, 1977.

    Article  Google Scholar 

  12. Goldberg LI, Toda N: Dopamine-induced relaxation of isolated canine renal, mesenteric, and femoral arteries contracted with prostaglandin F2. Circ Res 9: 384–389, 1975.

    Google Scholar 

  13. Goldberg LI, Hsieh YY: Drugs acting on the autonomic nervous system In Hurst JW, Logue RB, Schlant RC, Wanger NK (eds): The heart 4th ed. McGraw Hill, New York, pp 1980–1983, 1978.

    Google Scholar 

  14. Cohn J: Shock. In Hurst JW, Logue RB, Schlant RC, Wanger NK (eds): The heart 4th ed. McGraw Hill, New York, pp 716–727, 1978.

    Google Scholar 

  15. Goldberg LI, Talley RC, McNay JL: The potential role of dopamine in the treatment of shock. Prog Cardiovasc Dis 12: 40–51, 1969.

    Article  PubMed  CAS  Google Scholar 

  16. MacCannell KL, McNay JL, Meyer MB, Goldberg LI: The use of dopamine in the treatment of hypotension and shock. New Engl J Med 275: 1389–1398, 1966.

    Article  PubMed  CAS  Google Scholar 

  17. Talley RC, Goldberg LI, Johnson CE, McNay JL: Comparison of dopamine and isoproterenol in therapy of human shock. Circulation 39: 361–378, 1969.

    PubMed  CAS  Google Scholar 

  18. Henderson IS, Beattie TJ, Kennedy AC: Dopamine hydrochloride and oliguric states. Lancet 2:827– 828, 1980.

    PubMed  Google Scholar 

  19. Sprung CL, Caralis PV, Marciai EH, Pierce M, Gelbard MA, Long WM, Duncan RC, Tendier MD, Karpf M: The effects of high-dose corticosteroids in patients with septic shock. New Engl J Med 311: 1137–1143, 1984.

    Article  PubMed  CAS  Google Scholar 

  20. Greene SI, Smith JW: Dopamine gangrene. New Engl J Med 294: 114, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Mueller H, Ayres SM, Giannelli S Jr, et al.: Effect of isoproterenol, 1-norepinephrine, and intra-aortic counter pulsation on hemodynamics and myocardial metabolism in shock following acute myocardial infarction. Circulation 45: 335–351, 1972.

    PubMed  CAS  Google Scholar 

  22. Smythe CM, Nichol JF, Bradley SE: The effect of epinephrine (U.S.P.), 1-epinephrine, and 1-norepi- nephrine on glomerular filtration rate, renal plasma flow, and urinary excretion of sodium, potassium, and water in normal man. J Clin Invest 31:499– 506, 1952.

    Article  PubMed  Google Scholar 

  23. Sonnenblick EH, Frishman WH, LeJemtel TH: Do-butamine: a new synthetic cardioactive sympatho-mimetic amine. New Engl J Med 300: 17–22, 1979.

    Article  PubMed  CAS  Google Scholar 

  24. Ruffolo RR Jr, Yaden EL: Vascular effects of the stereo isomers of dobutamine. J Pharmacol Exp Ther 224: 46–50, 1983.

    PubMed  CAS  Google Scholar 

  25. Kuhn LA: Shock and myocardial infarction: medical treatment. Am J Cardiol 56: 578–587, 1970.

    Article  Google Scholar 

  26. Keung EC, Ribner HS, Schwartz W, et al.: Effects of combined dopamine and nitroprusside therapy in patients with severe pump failure and hypotension in acute myocardial infarction. J Cardiovasc Pharmacol 2: 113–119, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. Miller RR, Awan NA, Joye JA, et al.: Combined dopamine and nitroprusside therapy in congestive heart failure. Circulation 55: 881–884, 1977.

    PubMed  CAS  Google Scholar 

  28. Rajfer SI, Anton AH, Rossen J, Goldberg LI: Bene-ficial hemodynamic effects of oral levodopa in heart failure: relationship to the generation of dopamine. New Engl J Med 310: 1357–1362, 1984.

    Article  PubMed  CAS  Google Scholar 

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© 1986 Springer-Verlag New York Inc.

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Goldberg, L.I., Rajfer, S.I. (1986). Sympathomimetic Amines in the Treatment of Shock. In: Maronde, R.F. (eds) Topics in Clinical Pharmacology and Therapeutics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4864-4_12

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  • DOI: https://doi.org/10.1007/978-1-4612-4864-4_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9336-1

  • Online ISBN: 978-1-4612-4864-4

  • eBook Packages: Springer Book Archive

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