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Structure Activity Relationships of P2 Receptor Agonists and Antagonists

  • Chapter
The P2 Nucleotide Receptors

Part of the book series: The Receptors ((REC))

Abstract

With the cloning of numerous new subtypes (Burnstock and King, 1996) of P2 receptors, (belonging to P2X and P2Y super families),* for naturally occurring extracellular purine and pyrimidine nucleotides (structures shown in Fig. 1), ligand development is underway. It is clear that the P2 receptors are structurally distinct from adenosine, or P1, receptors (van Rhee et al., 1995), thus they have markedly different ligand binding requirements. The recently reorganized nomenclature of P2 receptors divides them into ligand-gated ion channels (P2X, of which seven subtypes have been cloned) and metabotropic G protein-coupled subtypes (P2Y, of which at least four subtypes have been cloned). At P2X receptors (see Chapter 2, this volume, for subtype designations) the most potent native nucleotide is adenosine triphos-phate (ATP), 1 (the numbers denote compounds in the figures), whereas at various subtypes of P2Y receptors (see Chapter 3, this volume) uridine triphosphate (UTP), 4, and/or diphosphates such as adenosine diphosphate (ADP), 2, may serve as agonists. Adenine dinucleotides, such as Ap4A, 3, may directly activate P2Y-type dinucleotide receptors, and may allosterically enhance activation of P2X receptors (King et al., 1996).

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Authors
  1. Kenneth A. Jacobson
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  2. Yong-Chul Kim
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  3. Emidio Camaioni
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  4. A. Michiel van Rhee
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Editors and Affiliations

  1. Department of Pharmacology, University of Missouri-Columbia, MO, USA

    John T. Turner  & Gary A. Weisman  & 

  2. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Jeffrey S. Fedan

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Jacobson, K.A., Kim, YC., Camaioni, E., van Rhee, A.M. (1998). Structure Activity Relationships of P2 Receptor Agonists and Antagonists. In: Turner, J.T., Weisman, G.A., Fedan, J.S. (eds) The P2 Nucleotide Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1800-5_4

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  • DOI: https://doi.org/10.1007/978-1-4612-1800-5_4

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