Abstract
Family and cytogenetic studies of testicular germ cell tumours (TGCT) suggest a strong genetic component in the aetiology of these tumours. We have focused upon genes that may play a key regulatory role in the development of germ cells. Following studies in the nematode worm, Caenorhabditis elegans [1], we have investigated the Notch gene family. Initial results indicate that members of the Notch family are expressed by primordial germ cells, and by seminoma and intratubular germ cell neoplasia, consistent with a possible role in tumour development (unpublished results).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Berry, L.W., Westlund, B., Schedl, T. Germ line tumour formation caused by activation of Glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development 124,925–936,1997
Murty VV, Montgomery K, Dutta S, Bala S, Renault B, Bosl GJ, Kucherlapati R, Chaganti RS. A 3-Mb high-resolution BAC/PAC contig of 12q22 encompassing the 830-kb consensus minimal deletion in male germ cell tumors. Genome Research 9:662–671,1999
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag London Limited
About this paper
Cite this paper
Adamah, D., Gokhale, P.J., Walsh, J., Andrews, P.W. (2002). A Notch-related Gene Located on the Long Arm of Human Chromosome 12. In: Harnden, P., Joffe, J.K., Jones, W.G. (eds) Germ Cell Tumours V. Springer, London. https://doi.org/10.1007/978-1-4471-3281-3_3
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3281-3_3
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3283-7
Online ISBN: 978-1-4471-3281-3
eBook Packages: Springer Book Archive