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Cysteine Proteases of Pathogenic Organisms pp 84–99Cite as

Cysteine Peptidases of Kinetoplastid Parasites

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 712))

Abstract

We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.

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Authors and Affiliations

  1. Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, Byers Hall, University of California San Francisco, San Francisco, USA

    Conor R. Caffrey

  2. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, C. C. S., Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil

    Ana-Paula Lima

  3. BioMedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK

    Dietmar Steverding

Authors
  1. Conor R. Caffrey
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  2. Ana-Paula Lima
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  3. Dietmar Steverding
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Editors and Affiliations

  1. Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney, Ultimo, Sydney, Australia

    Mark W. Robinson PhD

  2. Institute of Parasitology, McGill University, McDonald Campus, St. Anne de Bellevue, Quebec, Canada

    John P. Dalton PhD

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Caffrey, C.R., Lima, AP., Steverding, D. (2011). Cysteine Peptidases of Kinetoplastid Parasites. In: Robinson, M.W., Dalton, J.P. (eds) Cysteine Proteases of Pathogenic Organisms. Advances in Experimental Medicine and Biology, vol 712. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8414-2_6

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