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Biomolecule-Responsive Hydrogels

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Abstract

Biomolecule-responsive hydrogels that exhibit volume changes in response to target biomolecules have become increasingly important because of their potential applications as smart biomaterials. Researchers are developing novel biomedical systems using glucose, proteins and other biomolecule-responsive hydrogels as biosensing systems for applications such as drug delivery and cell culture systems. In the synthesis of biomolecule-responsive hydrogels, both biomolecular recognition and responsive functions that perceive a target biomolecule and induce structural changes must be introduced into the hydrogels network. Many biomolecule-responsive hydrogels are prepared by combining structural designs of hydrogels networks with molecular recognition events of biomolecules, such as enzymes, lectins and antibodies. Most important is the need to synthesize and develop more biomolecule-responsive hydrogels in tandem with their biomedical applications so that the field continues to evolve.

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Authors and Affiliations

  1. Department of Chemistry and Materials Engineering, Kansai University, Suita, Osaka, 564-8680, Japan

    Takashi Miyata

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  1. Takashi Miyata
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Correspondence to Takashi Miyata .

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Editors and Affiliations

  1. Virginia Commonwealth University, Richmond, 23284, Virgin Islands, USA

    Raphael M. Ottenbrite

  2. Dept. Biomedical Engineering, Purdue University, West Lafayette, 47907-1296, Indiana, USA

    Kinam Park

  3. Tokyo Women's Medical College, Kawada-cho Ichigaya 8-1, Tokyo, 162-8666, Japan

    Teruo Okano

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Miyata, T. (2010). Biomolecule-Responsive Hydrogels. In: Ottenbrite, R., Park, K., Okano, T. (eds) Biomedical Applications of Hydrogels Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5919-5_4

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