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Nitric Oxide (NO) and Cancer pp 39–57Cite as

Dual Role of Nitric Oxide in Cancer Biology

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Extensive research work performed over the past decades has focused on understanding the role of nitric oxide (NO) in both promoting and preventing cancer. The precise role of NO in tumor biology has been the cause of intense debate. Experimental evidences available in the literature highlight contrasting pro- and anti-tumor effects of NO. It is now becoming clear that concentration- and time-dependent regulation of NO leads to tumor growth, cytostasis, or cell death. It is known that NO participates in various signaling pathways including Ras, extracellular signal-regulated kinases (ERKs), Akt, cyclin D1/retinoblastoma (Rb) as mammalian target of rapamycin (mTOR) that are crucial for tumor cells. NO mediated post-translational modification of key proteins including S-nitrosylation of caspases, tyrosine nitration of mitochondrial manganese superoxide dismutase (MnSOD), or cytochrome c. Various attempts toward developing NO-based cancer therapy are still in primitive stages, and a clear understanding of the levels of NOS expression, its timing, and the concentrations of NO produced in the tumor microenvironment is key to the development of novel strategies for tumor treatment and prevention.

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Authors and Affiliations

  1. Division of Endocrinology, Charles Drew School of Medicine and Science, 3084A Hawkins Building, Los Angeles, CA, USA

    Shehla Pervin

  2. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Rajan Singh

  3. Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA, USA

    Rajan Singh

  4. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA

    Suvajit Sen & Gautam Chaudhuri

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  1. Shehla Pervin
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  2. Rajan Singh
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  4. Gautam Chaudhuri
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Correspondence to Shehla Pervin .

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  1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Charles E. Young Dr. E. 609, Los Angeles, 90095, California, USA

    Benjamin Bonavida

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Pervin, S., Singh, R., Sen, S., Chaudhuri, G. (2010). Dual Role of Nitric Oxide in Cancer Biology. In: Bonavida, B. (eds) Nitric Oxide (NO) and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1432-3_3

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