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A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins

  • Conference paper
Brain Edema XIII

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 96))

Summary

Brain ischemia leads to severe damage in the form of delayed neuronal cell death. In our study, we show that the marked neuroprotection of the new immunosuppressant FR901495 in forebrain ischemia is due not only to inhibition of calcineurin, but also to protection against mitochondrial damage caused by mitochondrial permeability transition pore formation through cyclophilin D, one of the prolyl cis/trans isomerase family members. These findings shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Hachioji Medical Center, Tokyo Medical University, 1163 Tate-machi, Hachioji, Tokyo, 193-0998, Japan

    H. Uchino & T. Takahashi

  2. Department of Neurosurgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan

    Y. Ikeda & N. Ishii

  3. Department of Molecular and Cell Physiology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    H. Uchino & F. Shibasaki

  4. Laboratory of Cellular Neurobiology, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

    S. Morota & Y. Kudo

  5. Arendala 702, 22478, Lund, Sweden

    B. K. Siesjö

Authors
  1. H. Uchino
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  2. S. Morota
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  3. T. Takahashi
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  4. Y. Ikeda
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  5. Y. Kudo
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  6. N. Ishii
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  7. B. K. Siesjö
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  8. F. Shibasaki
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA

    Julian T. Hoff , Richard F. Keep , Guohua Xi  & Ya Hua , ,  & 

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© 2006 Springer-Verlag

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Uchino, H. et al. (2006). A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins. In: Hoff, J.T., Keep, R.F., Xi, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_35

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  • DOI: https://doi.org/10.1007/3-211-30714-1_35

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-30712-0

  • Online ISBN: 978-3-211-30714-4

  • eBook Packages: MedicineMedicine (R0)

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