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Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease

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Book cover Lipid Signaling in Human Diseases

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 259))

Abstract

Lipids play a vital role in numerous cellular functions starting from a structural role as major constituents of membranes to acting as signaling intracellular or extracellular entities. Accordingly, it has been known for decades that lipids, especially those coming from diet, are important to maintain normal physiological functions and good health. On the other side, the exact molecular nature of these beneficial or deleterious lipids, as well as their precise mode of action, is only starting to be unraveled. This recent improvement in our knowledge is largely resulting from novel pharmacological, molecular, cellular, and genetic tools to study lipids in vitro and in vivo. Among these important lipids, phosphatidic acid plays a unique and central role in a great variety of cellular functions. This review will focus on the proposed functions of phosphatidic acid generated by phospholipase D in the last steps of regulated exocytosis with a specific emphasis on hormonal and neurotransmitter release and its potential impact on different neurological diseases.

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Authors and Affiliations

  1. Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212 and Université de Strasbourg, Strasbourg, France

    Emeline Tanguy, Qili Wang & Nicolas Vitale

  2. INSERM, Paris, Cedex 13, France

    Nicolas Vitale

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  1. Emeline Tanguy
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  2. Qili Wang
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Correspondence to Nicolas Vitale .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA

    Julian Gomez-Cambronero

  2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA

    Michael A. Frohman

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Tanguy, E., Wang, Q., Vitale, N. (2018). Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease. In: Gomez-Cambronero, J., Frohman, M. (eds) Lipid Signaling in Human Diseases. Handbook of Experimental Pharmacology, vol 259. Springer, Cham. https://doi.org/10.1007/164_2018_180

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