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Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep

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Sleep-Wake Neurobiology and Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 253))

Abstract

Central disorders of hypersomnolence are characterized by daily periods of irrepressible need to sleep or daytime lapses into sleep, as defined in the current version of the International Criteria of Sleep Disorders. Thus, the unifying symptom is excessive daytime sleepiness which is not caused by any other sleep-wake disorder. Relevant disorders including narcolepsy type 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, and insufficient sleep syndrome will be discussed. Other central disorders of hypersomnolence include hypersomnias due to medical or psychiatric disorders or because of medication or substance use.

In sleep-related movement disorders, the cardinal symptom consists of simple, often stereotyped movements occurring during sleep. The most frequent disorder in this category of sleep-wake disorders is restless legs syndrome, which is often associated with period limb movements during sleep.

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References

  • Ali M, Auger RR, Slocumb NL et al (2009) Idiopathic hypersomnia: clinical features and response to treatment. J Clin Sleep Med 5(6):562–568

    PubMed  PubMed Central  Google Scholar 

  • Allen RP, Picchietti DL, Garcia-Borreguero D et al (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance. Sleep Med 15(8):860–873

    Article  PubMed  Google Scholar 

  • Allen RP, Picchietti DL, Auerbach M et al (2018) Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Med 41:27–44

    Article  PubMed  Google Scholar 

  • American Academy of Sleep Medicine (AASM) (2014) The International Classification of Sleep Disorders – third edition (ICSD-3). American Academy of Sleep Medicine, Darien

    Google Scholar 

  • Antelmi E, Provini F (2015) Propriospinal myoclonus: the spectrum of clinical and neurophysiological phenotypes. Sleep Med Rev 22:54–63

    Article  PubMed  Google Scholar 

  • Arnulf I (2015) Kleine-Levin syndrome. Sleep Med Clin 10:151–161

    Article  PubMed  Google Scholar 

  • Arnulf I, Lin L, Gadoth N et al (2008) Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol 63:482–493

    Article  CAS  PubMed  Google Scholar 

  • Bassetti CL, Bornatico F, Fuhr P, Schwander J, Kallweit U, Mathis J, Swiss RLS study group (2011) Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial. Swiss Med Wkly w13274:141

    Google Scholar 

  • Baumann CR, Mignot E, Lammers GJ et al (2014) Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Sleep 37(6):1035–1042

    Article  PubMed  PubMed Central  Google Scholar 

  • Bayard M, Bailey B, Acharya D et al (2011) F. Bupropion and restless legs syndrome: a randomized controlled trial. J Am Board Fam Med 24(4):422–428

    Article  PubMed  Google Scholar 

  • Cippà MA, Baumann CR, Siccoli MM, Bassetti CL, Poryazova R, Werth E (2013) Actigraphic assessment of periodic leg movements in patients with restless legs syndrome. J Sleep Res 22(5):589–592

    Article  PubMed  Google Scholar 

  • Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ (2011) Profile of altered brain iron acquisition in restless legs syndrome. Brain 134(Pt 4):959–968

    Article  PubMed  PubMed Central  Google Scholar 

  • Cvetkovic-Lopes V, Bayer L, Dorsaz S et al (2010) Elevated tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest 120(3):713–719

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Earley CJ, Connor J, Garcia-Borreguero D et al (2014) Altered brain iron homeostasis and dopaminergic function in restless legs syndrome (Willis-Ekbom disease). Sleep Med 15(11):1288–1301

    Article  PubMed  Google Scholar 

  • Garcia-Borreguero D, Silber MH, Winkelman JW et al (2016) Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med 21:1–11

    Article  PubMed  Google Scholar 

  • Haba-Rubio J, Marti-Soler H, Marques-Vidal P et al (2016) Prevalence and determinants of periodic limb movements in the general population. Ann Neurol 79(3):464–474

    Article  PubMed  Google Scholar 

  • Hallmayer J, Faraco J, Lin L et al (2009) Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 41(6):708–711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hening WA, Allen RP, Washburn M, Lesage SR, Earley CJ (2009) The four diagnostic criteria for Restless Legs Syndrome are unable to exclude confounding conditions (“mimics”). Sleep Med 10(9):976–981

    Article  PubMed  PubMed Central  Google Scholar 

  • Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K, Koskimies S, Guilleminault C (1994) The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol 35(6):709–716

    Article  CAS  PubMed  Google Scholar 

  • Iber C, Ancoli-Israel S, Chesson A et al (2007) The AASM manual for the scoring of sleep and associated events. American Academy of Sleep Medicine, Westchester

    Google Scholar 

  • John J, Thannickal TC, McGregor R et al (2013) Greatly increased numbers of histamine cells in human narcolepsy with cataplexy. Ann Neurol 74(6):786–793

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kecklund G, Axelsson J (2016) Health consequences of shift work and insufficient sleep. BMJ 355:i5210

    Article  PubMed  Google Scholar 

  • Koo BB (2015) Restless leg syndrome across the globe: epidemiology of the restless legs syndrome/Willis-Ekbom disease. Sleep Med Clin 10(3):189–205

    Article  PubMed  Google Scholar 

  • Kornum BR, Knudsen S, Ollila HM, Pizza F, Jennum PJ, Dauvilliers Y, Overeem S (2017) Narcolepsy. Nat Rev Dis Primers 3:16100

    Article  PubMed  Google Scholar 

  • Kretzschmar U, Werth E, Sturzenegger C et al (2016) Which diagnostic findings in disorders with excessive daytime sleepiness are really helpful? A retrospective study. J Sleep Res 25(3):307–313

    Article  PubMed  Google Scholar 

  • Lavault S, Golmard J, Groos E et al (2015) Kleine-Levin syndrome in 120 patients: differential diagnosis and long episodes. Ann Neurol 77:529–540

    Article  PubMed  Google Scholar 

  • Lee YJ, Park J, Kim S, Cho SJ, Kim SJ (2015) Academic performance among adolescents with behaviorally induced insufficient sleep syndrome. J Clin Sleep Med 11(1):61–68

    PubMed  PubMed Central  Google Scholar 

  • Maric A, Montvai E, Werth E et al (2017) Insufficient sleep: enhanced risk-seeking relates to low local sleep intensity. Ann Neurol 82(3):409–418

    Article  PubMed  Google Scholar 

  • Marti I, Valko PO, Khatami R, Bassetti CL, Baumann CR (2009) Multiple sleep latency measures in narcolepsy and behaviourally induced insufficient sleep syndrome. Sleep Med 10:1146–1150

    Article  PubMed  Google Scholar 

  • Mayer G, Benes H, Young P et al (2015) Modafinil in the treatment of idiopathic hypersomnia without long sleep time-a randomized, double-blind, placebo-controlled study. J Sleep Res 24(1):74–81

    Article  PubMed  Google Scholar 

  • Mignot E, Lin L, Rogers W et al (2001) Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 68(3):686–699

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morita Y, Sasai-Sakuma T, Asaoka S, Inoue Y (2015) Prevalence and correlates of insufficient sleep syndrome in Japanese young adults: a web-based cross-sectional study. J Clin Sleep Med 11:1163–1169

    Article  PubMed  PubMed Central  Google Scholar 

  • Neikrug AB, Crawford MR, Ong JC (2017) Behavioral sleep medicine services for hypersomnia disorders: a survey study. Behav Sleep Med 15(2):158–171

    Article  PubMed  Google Scholar 

  • Ohayon MM, Reynolds CF 3rd, Dauvilliers Y (2013) Excessive sleep duration and quality of life. Ann Neurol 73(6):785–794

    Article  PubMed  PubMed Central  Google Scholar 

  • Ozaki A, Inoue Y, Hayashida K et al (2012) Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: comparison between patients on psychostimulants, drug-naive patients and the general Japanese population. Sleep Med 13(2):200–206

    Article  PubMed  Google Scholar 

  • Papacostas SS, Hadjivasilis V (2000) The Kleine-Levin syndrome. Report of a case and review of the literature. Eur Psychiatry 15:231–235

    Article  CAS  PubMed  Google Scholar 

  • Peyron C, Faraco J, Rogers W et al (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6(9):991–997

    Article  CAS  PubMed  Google Scholar 

  • Philip P, Chaufton C, Taillard J et al (2014) Modafinil improves real driving performance in patients with hypersomnia: a randomized double-blind placebo-controlled crossover clinical trial. Sleep 37(3):483–487

    Article  PubMed  PubMed Central  Google Scholar 

  • Pizza F, Antelmi E, Vandi S et al (2018) The distinguishing motor features of cataplexy: a study from video recorded attacks. Sleep [Epub ahead of print]

    Google Scholar 

  • Ruoff C, Pizza F, Trotti LM et al (2018) The MSLT is repeatable in narcolepsy type 1 but not narcolepsy type 2: a retrospective patient study. J Clin Sleep Med 14(1):65–74

    Article  PubMed  PubMed Central  Google Scholar 

  • Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257–1263

    Article  CAS  PubMed  Google Scholar 

  • Scammell TE (2015) Narcolepsy. N Engl J Med 373(27):2654–2662

    Article  CAS  PubMed  Google Scholar 

  • Stefansson H, Rye DB, Hicks A et al (2007) A genetic risk factor for periodic limb movements in sleep. N Engl J Med 357(7):639–647

    Article  CAS  PubMed  Google Scholar 

  • Szakacs Z, Dauvilliers Y, Mikhaylov V et al (2017) Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16(3):200–207

    Article  CAS  PubMed  Google Scholar 

  • Taddei RN, Werth E, Poryazova R, Baumann CR, Valko PO (2016) Diagnostic delay in narcolepsy type 1: combining the patients’ and the doctors’ perspectives. J Sleep Res 25(6):709–715

    Article  PubMed  Google Scholar 

  • Thannickal TC, Moore RY, Nienhuis R et al (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27(3):469–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trotti LM (2017) Idiopathic hypersomnia. Sleep Med Clin 12(3):331–344

    Article  PubMed  PubMed Central  Google Scholar 

  • Trotti LM, Staab BA, Rye DB (2013) Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. J Clin Sleep Med 9(8):789–795

    PubMed  PubMed Central  Google Scholar 

  • Trotti LM, Saini P, Bliwise DL et al (2015) Clarithromycin in gamma-aminobutyric acid-related hypersomnolence: a randomized, crossover trial. Ann Neurol 78(3):454–465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valko PO, Gavrilov YV, Yamamoto M et al (2013) Increase of histaminergic tuberomammillary neurons in narcolepsy. Ann Neurol 74(6):794–804

    Article  CAS  PubMed  Google Scholar 

  • Van Dongen HP, Maislin G, Mullington JM, Dinges DF (2003) The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26(2):117–126

    Article  PubMed  Google Scholar 

  • Winkelmann J, Schormair B, Lichtner P et al (2007) Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 39(8):1000–1006

    Article  CAS  PubMed  Google Scholar 

  • Winkelmann J, Czamara D, Schormair B et al (2011) Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet 7(7):e1002171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Conflicts of Interest

Dr. Baumann reports no conflicts of interests in regard to this work.

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Authors and Affiliations

  1. Department of Neurology, University Hospital Zurich, University of Zurich, Zürich, Switzerland

    Christian R. Baumann

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  1. Christian R. Baumann
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Correspondence to Christian R. Baumann .

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Editors and Affiliations

  1. Human Sleep Psychopharmacology Laboratory, Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland

    Hans-Peter Landolt

  2. Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

    Derk-Jan Dijk

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Baumann, C.R. (2018). Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep. In: Landolt, HP., Dijk, DJ. (eds) Sleep-Wake Neurobiology and Pharmacology . Handbook of Experimental Pharmacology, vol 253. Springer, Cham. https://doi.org/10.1007/164_2018_126

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