Bioinformatics and Computational Biology Solutions Using R and Bioconductor

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R.

This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms:

Curation and delivery of biological metadata for use in statistical modeling and interpretation

Statistical analysis of high-throughput data, including machine learning and visualization

Modeling and visualization of graphs and networks

The developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies.

This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

• Annotation
• DNA
• Processing
• bioinformatics
• biology
• calculus
• classification
• cluster analysis
• data analysis
• genes
• genome
• genomics
• machine learning
• microarray
• protein

From the reviews:

"The book has several nice touches that readers will appreciate. First, the liberal use of color shows the full capabilities of Bioconductor pakages and brings the material to life. Second, color figures are dispersed throughout the text rather than being relegated to a central section of color plates. Third, the index indicates whether a term references a package, function or class. This book is an excellent resource... In summary, this book is a must have for any Bioconductor user." (J. Wade Davis, Journal of the American Statistical Association, Vol. 102, No. 477, 2007)

"This book is solid evidence of the influence that quantitative researchers can have on biological investigations. Organized into separate chapters of shared authorship, the book provides a valuable overview of the impact that the authors and their colleagues have had on the analysis of genomic data." (R.W. Doerge, Biostatistics, December 2006)

"This book provides an in-depth demonstration of the potential of the Bioconductor project, through a varied mixture of descriptions, figures and examples. … The book … is an exciting opportunity for researchers to learn directly from the software developers themselves. The range of material covered by the book is diverse and well structured. An abundance of fully worked case studies illustrate the methods in practice. … it should be a must for any researcher considering getting started with the software … ." (Rebecca Walls, Journal of Applied Statistics, Vol. 34 (3), 2007)

"The book provides an extensive overview over the most important tasks in analyzing genomic data with Bioconductor. … The book is well written and communicates hands-on experience of the developers of the respective Bioconductor packages themselves. … The book is targeted to a broad range of researchers interested in genomic data analysis, including biologists, bioinformaticians, and statisticians. … It is a very valuable resource formodern genomic data analysis. There is no comparable book on the market." (Jörg Rahnenführer, Statistical Papers, Vol. 50, 2009)

• Program in Computational Biology Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA

  Robert Gentleman

• Channing Laboratory Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

  Vincent J. Carey

• European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK

  Wolfgang Huber

• Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA

  Rafael A. Irizarry

• Division of Biostatistics School of Public Health, University of California Berkeley, Berkeley, USA

  Sandrine Dudoit

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