Peptides for the New Millennium

1. Front Matter

   Pages i-lxvii

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2. The 1999 Merrifield Award/Rao Makineni Lecture

   1. Front Matter

      Pages 1-2

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   2. Mimetic peptides, demanding enzymes and drug discovery

      • Daniel H. Rich

      Pages 3-16

3. Young Investigators’ MiniSymposium (dedicated to the memory of Bruce W. Erickson)

   1. Front Matter

      Pages 17-18

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   2. Bruce W. Erickson: In memoriam

      • Arthur M. Felix

      Pages 19-19

   3. Engineering of a cysteine-containing variant of quadrin, a protein containing the oligomerization site of the hepatitis delta antigen

      • Matthew J. Saderholm, Paul Saconn, Nimish Shah, Bruce W. Erickson

      Pages 20-21

   4. Characterization of betabellins 15D and 16D, designed beta-sandwich proteins that have amyloidogenic properties

      • Amareth Lim, Alexander M. Makhov, Lawreen H. Connors, Jeremy Bond, Hideyo Inouye, Jack D. Griffith et al.

      Pages 22-23

   5. Design and synthesis of inhibitors of botulinum neurotoxin A and B metalloproteases

      • Thorsten K. Oost, Chanokporn Sukonpan, Daniel H. Rich

      Pages 24-25

   6. Dimerization inhibitors of HIV-1 protease: Effective inhibition requires the cross-linking of non-identical peptides

      • Michael D. Shultz, Jean Chmielewski

      Pages 26-27

   7. Backbone cyclic proteinomimetics derived from the arginine-rich domain of HIV-1 Tat and Rev proteins: One sequence, two conformations, two biological functions

      • Assaf Friedler, Nathan Luedtke, Dorit Friedler, Abraham Loyter, Yitzhak Tor, Chaim Gilon

      Pages 28-29

   8. Synthesis of several O-glycopeptide analogs of enkephalin

      • Scott A. Mitchell, Matthew R. Pratt, Victor J. Hruby, Robin Polt

      Pages 30-31

   9. Investigating the role of turns in the folding of a predominantly β-sheet protein

      • Kenneth S. Rotondi, Kannan Gunasekaran, Lila M. Gierasch

      Pages 32-33

   10. Receptor-bound conformations of integrin αIIbβ3 antagonists by 15N-edited NMR spectroscopy

       • Elsa Locardi, Ralph-Heiko Mattern, Timothy I. Malaney, Daniel G. Mullen, Robert Minasyan, Michael D. Pierschbacher et al.

       Pages 34-35

   11. Design, synthesis, and characterization of two core modules of bovine pancreatic trypsin inhibitor

       • Natalia Carulla, Clare Woodward, George Barany

       Pages 36-37

   12. The fine tuning of high affinity and selective non-peptide agonists of the δ-opioid receptor via solution and solid-phase

       • Josue Alfaro-Lopez, Toru Okayama, Keiko Hosohata, Peg Davis, Frank Porreca, Henry I. Yamamura et al.

       Pages 38-39

   13. Cyclic dodecapeptides (LLLD)3 form ion channels in lipid bilayers

       • Dongxia Wang, Lili Guo, Patrick J. Edwards, Larry R. Jones, Roger W. Roeske

       Pages 40-41

   14. Synthesis and evaluation of potential affinity labels for opioid receptors

       • Heekyung Choi, Thomas F. Murray, Jane V. Aldrich

       Pages 42-43

4. Synthetic Methodologies (including Large-Scale Synthesis)

   1. Front Matter

      Pages 45-45

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   2. Polyethyleneglycol-based chains of precise length for chemobodies

      • Keith Rose, Jean Vizzavona

      Pages 47-49

   3. N^α-2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as an amino-protecting group and its application for peptide synthesis

      • Hack-Joo Kim, Vladimir V. Samukov

      Pages 50-52

“Have you tried peptides? Small proteins, the best in the land! Won’t you try peptides? Keep all your body processes in hand! For labor and lactation oxytocin you must buy! Enkephalin always gives a good runner’s high! So won’t you try peptides? Small proteins, the best in the land!” The above words [1], penned by Gary Gisselman to open Peptide Ångst: La Triviata, the opera which made its world premiere on July 1, 1999, also serve as a fitting charge to the th 16 American Peptide Symposium. This latest edition of a premier biennial series was held under the auspices of the American Peptide Society, June 26–July 1, 1999, at the Minneapolis Convention Center, Minneapolis,Minnesota, with the undersigned serving as Co-Chairs. The fortunate coincidence of the calendar allowed us to set as the theme “Peptides for the New Millennium”, and in our judgment, the approximately 1200 participants [2] who converged in the Twin Cities from academic and industrial institutions in 36 countries were treated to an exciting and stimulating conference that left most everyone with an enthusiastic vision for the future of our field. The present Proceedings volume should serve as a handy reference source and succinct snapshot of peptide science at essentially its century mark – the clock having started with the initial contributions of Emil Fischer and Th. Curtius.

• chemistry
• enzyme
• enzymes
• organic synthesis
• protein
• receptor
• synthesis

• Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, USA

  Gregg B. Fields

• Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, USA

  James P. Tam

• Departments of Chemistry and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, USA

  George Barany

Policies and ethics