Abstract
The present study has been designed to investigate the efficacy of various extracts of Allium humile leaves to limit ischaemia and reperfusion-induced myocardial injury in wister albino rats. Various extracts of Allium humile leaves were prepared viz. Pet.ether, chloroform, acetone and methanol. These extracts evaluated for cardioprotective effect. Isolated perfused rat heart was subjected to global ischaemia for 30 min. followed by reperfusion for 120 min. Coronary effluent was analysed for LDH and CK-MB release to assess the degree of cardiac injury. Myocardial infarct size was estimated macroscopically using TTC staining by volume method. The present study demonstrates that methanolic extract of Allium humile leaves significantly prevented myocardial infarct size and markedly reduced LDH and CK-MB release in coronary effluent at dose level of 100 mg/kg body weight as compared with that of standard ramipril (1 mg/kg body weight). These results suggest that cardioprotective effect of methanolic extract of Allium humile was found significant (p < 0.05) as compared to vehicle control group.
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The authors gratefully acknowledge to Director and management of SBSPGI, Balawala, Dehradun, India for providing the necessary facilities during this experimental study
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Dobhal, Y., Parcha, V. & Dhasmana, D.C. Cardioprotective potential of Allium humile leaves extract. Orient Pharm Exp Med 14, 157–162 (2014). https://doi.org/10.1007/s13596-013-0115-5
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DOI: https://doi.org/10.1007/s13596-013-0115-5