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A let-7 KRAS rs712 polymorphism increases colorectal cancer risk

  • Research Article
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Tumor Biology

Abstract

Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer. We aimed to investigate the association between let-7 KRAS rs712 polymorphism and the risk of colorectal cancer (CRC). The let-7 KRAS rs712 was analyzed in a case–control study, including 339 CRC patients and 313 age- and sex-matched controls; the relationship between the polymorphism and the clinicopathological features of CRC was also examined. Individuals carrying the let-7 KRAS rs712 TT genotype and T allele had an increased risk of developing CRC (TT vs. GG, adjusted OR = 2.18; 95 % CI, 1.00–4.77; T vs. G, adjusted OR = 1.50; 95 % CI, 1.15–1.96). Stratified analyses revealed that CRC patients with the let-7 KRAS rs712 TT genotype were more likely to have clinical stage III or IV disease (OR = 3.29, 95 % CI, 1.32–8.20) and distant metastasis (OR = 4.70, 95 % CI, 1.81–12.25). These findings provide evidence that the let-7 KRAS rs712 polymorphism may play crucial roles in the etiology of CRC.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (no. 81302149), Natural Science Foundation of the Science and Technology Department of Henan Province (no. 132300410105), the Ph.D. Scientific Research Foundation of Henan University of Science and Technology (no. 09001492).

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Authors and Affiliations

  1. Department of Forensic Pathology, College of Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, 471003, People’s Republic of China

    Xin-Min Pan, Zhen Zhang, Hao-Jie Qin & Guo-Hui Xu

  2. Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, 650500, Yunnan, People’s Republic of China

    Rui-Fen Sun

  3. Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, 471003, People’s Republic of China

    Zhao-Hui Li

  4. Department of Otolaryngology, Third Affiliated Hospital of Henan University of Science and Technology and Luo Yang East Hospital, Luoyang, Henan, 471003, People’s Republic of China

    Xiao-Min Guo

  5. Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China

    Lin-Bo Gao

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  1. Xin-Min Pan
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Correspondence to Xin-Min Pan.

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Xin-Min Pan and Rui-Fen Sun contributed equally to this work.

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Pan, XM., Sun, RF., Li, ZH. et al. A let-7 KRAS rs712 polymorphism increases colorectal cancer risk. Tumor Biol. 35, 831–835 (2014). https://doi.org/10.1007/s13277-013-1114-3

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  • DOI: https://doi.org/10.1007/s13277-013-1114-3

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