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Development of 166Ho-phytate Complex for Radiosynovectomy

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Abstract

Background

66Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5 × 1013 n.cm-2.s-1).

Methods

166Ho-holmium chloride (185 MBq) was used successfully for preparation of 166Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 μCi/100 μl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days.

Results

Approximately all of the injected dose had remained in the injection site 2 days after injection.

Conclusion

The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.

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Conflict of Interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, 14155-1339

    Amir R. Jalilian, Ali Bahrami-Samani, Mohammad Mazidi & Mohammad Ghannadi-Maragheh

  2. Faculty of Nuclear Engineering, Shahid Beheshti University, P.O. Box: 19839-63113, Tehran, Iran

    Akbar Anvari

Authors
  1. Amir R. Jalilian
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  2. Akbar Anvari
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  3. Ali Bahrami-Samani
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  4. Mohammad Mazidi
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  5. Mohammad Ghannadi-Maragheh
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Correspondence to Amir R. Jalilian.

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Jalilian, A.R., Anvari, A., Bahrami-Samani, A. et al. Development of 166Ho-phytate Complex for Radiosynovectomy. Nucl Med Mol Imaging 45, 87–92 (2011). https://doi.org/10.1007/s13139-010-0048-6

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  • DOI: https://doi.org/10.1007/s13139-010-0048-6

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