Abstract
Acute kidney injury (AKI) is one of the most dreaded complications of severe malaria. Herein, we report a case of spontaneous resolution of AKI due to collapsing glomerulopathy (CG) and hemolytic-uremic syndrome (HUS) associated with P. falciparum malaria. Our case report highlights the fact that early intervention on the triggering cause of CG without a long course of steroids may obtain a remission of this severe subset of CG and may obtain a remission of HUS without therapeutic plasmapheresis The etiologic treatment of CG and HUS may avoid progression to end-stage renal disease.
References
Adonis-koffy L (2004) May Plasmodium falciparum induce a hemolytic uremic syndrome? Arch Pediatr 11(1):55–56
Albaqumi M, Soos TJ, Barisoni L, Nelson PJ (2006) Collapsing glomerulopathy. J Am Soc Nephrol 17(10):2854–2863
Barri YM, Munshi NC, Sukumalchantra S, Abulezz SR, Bonsib SM, Wallach J et al (2004) Podocyte injury associated glomerulopathies induced by pamidronate. Kidney Int 65:634–641
Das BS (2008) Renal failure in malaria. J Vector Borne Dis 45:83–97
Eiam-Ong S (2003) Malarial nephropathy. Semin Nephrol 23(1):21–33
Eiam-Ong S, Sitprija V (1998) falciparum malaria and the kidney: a model of inflammation. Am J Kidney Dis 32:361–375
Elsheikha HM (2007) Sheashaa HA Epidemiology, pathophysiology, management and outcome of renal dysfunction associated with plasmodia infection. Parasitol Res 101(5):1183–1190
Herlitz LC, Markowitz GS, Farris AB, Schwimmer JA, Stokes MB, Kunis C et al (2010) Development of focal segmental glomerulosclerosis after anabolic steroid abuse. J Am Soc Nephrol 21:163–172
Ishikura K, Hamasaki Y, Sakai T, Hataya H, Mak RH, Honda M (2012) Posterior reversible encephalopathy syndrome in children with kidney diseases. Pediatr Nephrol 27(3):375–384
Jha V, Chugh KS (2008) Community-acquired acute kidney injury in Asia. Semin Nephrol 28:330–347
Mishra SK, Das BS (2008) Malaria and acute kidney injury. Semin Nephrol 28:395–408
Niang A, Niang SE, el Ka HF, Ka MM, Diouf B (2008) Collapsing glomerulopathy and haemophagocytic syndrome related to malaria: a case report. Nephrol Dial Transplant 23(10):3359–3361
Pascual J, Torrealba J, Myers J, Tome S, Samaniego M, Musat A et al (2007) Collapsing focal segmental glomerulosclerosis in a liver transplant recipient on alendronate. Osteoporos Int 18:1435–1438
Prakash J, Singh AK, Kumar NS, Saxena RK (2003) Acute renal failure in Plasmodium vivax malaria. J Assoc Physicians India 51:265–267
Ruggenenti P, Noris M, Remuzzi G (2001) Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 60(3):831–846
Schwartz MM, Evans J, Bain R, Korbet SM (1999) Focal segmental glomerulosclerosis: prognostic implications of the cellular lesion. J Am Soc Nephrol 10:1900–1907
Schwimmer JA, Markowitz GS, Valeri A, Appel GB (2003) Collapsing glomerulopathy. Semin Nephrol 23(2):209–218
Sharma J, Bharadawa K, Shah K, Dave S (1993) Plasmodium vivax malaria presenting as hemolytic-uremic Syndrome. Indian Pediatr 30(3):369–371
Tostivint I, Mougenot B, Flahault A, Vigneau C, Costa MA, Haymann JP et al (2002) Adult haemolytic and uraemic syndrome: causes and prognostic factors in the last decade. Nephrol Dial Transplant 17(7):1228–1234
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Kute, V.B., Trivedi, H.L., Vanikar, A.V. et al. Collapsing glomerulopathy and hemolytic uremic syndrome associated with falciparum malaria: completely reversible acute kidney injury. J Parasit Dis 37, 286–290 (2013). https://doi.org/10.1007/s12639-012-0164-6
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DOI: https://doi.org/10.1007/s12639-012-0164-6