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Feasibility of cord blood transplantation in chemosensitive adult T-cell leukemia/lymphoma: a retrospective analysis of the Nagasaki Transplantation Network

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Abstract

It has been reported that cord blood transplantation (CBT) for patients with aggressive adult T-cell leukemia/lymphoma (ATL) results in poorer outcomes than transplantation using other stem cell sources. To identify a subset of ATL in which CBT is feasible, we retrospectively analyzed 27 patients treated with CBT at three institutions in Nagasaki Prefecture, Japan. The estimated overall survival (OS) rate at 3 years was 27.4 %. Of 16 patients who received CBT during remission (complete, CR, or partial, PR), the OS rate at 3 years was 50 %, while during refractory periods (non-CR or non-PR), the OS rate was 9.1 %. Reduced intensity conditioning (RIC) was given to 18 patients, and myeloablative conditioning (MAC) was used in nine, with 3-year OS of 50.0 and 0 %, respectively. Of the 19 deaths, nine were due to progressive disease, eight (five MAC and three RIC) to infection, and two to multiple organ failure. These results suggest that CBT provides similar results with those in other transplantation procedures for selected ATL patients, such as those in CR or PR. Further studies are needed to evaluate the use of CBT in aggressive ATL.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Takuya Fukushima, Hidehiro Itonaga, Jun Taguchi, Yoshitaka Imaizumi, Daisuke Imanishi, Hideki Tsushima, Yasushi Sawayama, Tomoko Hata & Yasushi Miyazaki

  2. Laboratory of Hematoimmunology, Department of Clinical Laboratory Sciences, Faculty of Medicine, School of Health Sciences, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan

    Takuya Fukushima

  3. Sasebo City General Hospital, Sasebo, Japan

    Yukiyoshi Moriuchi

  4. National Hospital Organization Nagasaki Medical Center, Ohmura, Japan

    Shinichiro Yoshida & Emi Matsuo

Authors
  1. Takuya Fukushima
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  2. Hidehiro Itonaga
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  3. Yukiyoshi Moriuchi
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  4. Shinichiro Yoshida
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  5. Jun Taguchi
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  6. Yoshitaka Imaizumi
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  7. Daisuke Imanishi
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  8. Hideki Tsushima
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  9. Yasushi Sawayama
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  10. Emi Matsuo
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  11. Tomoko Hata
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  12. Yasushi Miyazaki
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Corresponding author

Correspondence to Takuya Fukushima.

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Fukushima, T., Itonaga, H., Moriuchi, Y. et al. Feasibility of cord blood transplantation in chemosensitive adult T-cell leukemia/lymphoma: a retrospective analysis of the Nagasaki Transplantation Network. Int J Hematol 97, 485–490 (2013). https://doi.org/10.1007/s12185-013-1307-y

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  • DOI: https://doi.org/10.1007/s12185-013-1307-y

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