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Significance of telomere capture in myelodysplastic syndromes

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Abstract

Addition of telomeres to the ends of broken chromosomes has been observed in many malignant cells through the capture of the ends of other chromosomes as a result of nonreciprocal translocations. In this study, we aimed to evaluate the percentage of nuclei with telomere capture (TC%) as a prognostic marker in myelodysplastic syndromes (MDS) patients. This study included 45 newly diagnosed MDS patients, 36 cases with denovo MDS and 9 cases with therapy-related MDS, and another 35 apparently healthy volunteers as a control group. Telomere capture percentage was investigated with fluorescent in situ hybridization technique using a probe for 15qter. We found that median TC% rate was significantly increased in those with bad cytogenetic abnormalities, patients with blast cells >10 % in BM, and patients categorized as high risk according to WHO and IPSS classification; also, there was a significant negative correlation with progression-free survival. Telomere capture serves as a useful marker for the assessment of MDS patient’s risk, and also it had a clinical importance for the early detection of disease progression.

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Acknowledgments

We gratefully thank all participating subjects for cooperation and support to this study. We also acknowledge Prof. Maha M Atfy for her assistance and guidance.

Conflict of interest

The authors have no conflicts of interest or funding support.

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Authors and Affiliations

  1. Clinical Pathology Department, Faculty of Medicine, Zagazig University, 9 Taleat Harb Street, Zagazig, 44155, Egypt

    Hany A. Labib

  2. Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Sheren Elshorbagy

  3. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Neveen G. Elantonuy

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  1. Hany A. Labib
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  2. Sheren Elshorbagy
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  3. Neveen G. Elantonuy
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Correspondence to Hany A. Labib.

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Labib, H.A., Elshorbagy, S. & Elantonuy, N.G. Significance of telomere capture in myelodysplastic syndromes. Med Oncol 31, 216 (2014). https://doi.org/10.1007/s12032-014-0216-0

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