Abstract
Primary spinal cord tumors constitute 2% to 4% of all central nervous system neoplasms and are characterized based on their location as intramedullary, intradural extramedullary, and extradural. A contemporary literature review of primary intradural spinal cord tumors was performed. Among intramedullary tumors, ependymomas are more common and often can be surgically resected. However, astrocytomas infiltrate the spinal cord and complete resection is rare. Intradural extramedullary tumors include schwannomas, neurofibromas, and meningiomas and are usually amenable to surgical resection. Radiotherapy is reserved for malignant variants and recurrent gliomas, whereas chemotherapy is administered for recurrent primary spinal cord tumors without surgical or radiotherapy options. Early recognition of the signs and symptoms related to primary spinal cord tumors facilitates timely discovery, treatment, potentially minimizes neurologic morbidity, and may improve outcome. Treatment consists of surgical resection, and predictors of outcome include preoperative functional status, histologic grade of tumor, and extent of surgical resection.
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Chamberlain, M.C., Tredway, T.L. Adult Primary Intradural Spinal Cord Tumors: A Review. Curr Neurol Neurosci Rep 11, 320–328 (2011). https://doi.org/10.1007/s11910-011-0190-2
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DOI: https://doi.org/10.1007/s11910-011-0190-2
Keywords
- Primary spinal cord tumors
- Intradural intramedullary
- Intradural extramedullary
- Extradural tumors
- Gliomas
- Low-grade glioma
- High-grade glioma
- Glioblastoma
- Ependymoma
- Hemangioblastoma
- Spinal cord parenchymal metastasis
- Meningioma
- Peripheral nerve sheath tumor
- Neurofibroma
- Schwannoma
- Extradural metastasis
- Resective surgery
- Biopsy
- Radiotherapy
- Chemotherapy
- Alkylator-based chemotherapy
- Temozolomide
- Platinoids
- Etoposide
- Bevacizumab