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Natural neo acids and neo alkanes: Their analogs and derivatives

  • Review
  • Published:
Lipids

Abstract

This review presents more than 260 naturally occurring (as well as 47 synthesized) neo fatty (carboxylic) acids, neo alkanes, and their analogs and derivatives, isolated and identified from plants, algae, fungi, marine invertebrates, and microorganisms, that demonstrate different biological activities. These natural metabolites are good prospects for future chemical preparations as antioxidants, and also as anticancer, antimicrobial, and antibacterial agents. Described also are some synthetic bioactive compounds containing a tertiary butyl group(s) that have shown high anticancer, antifungal, and other activities. Applications of some neo fatty (carboxylic) acid derivatives in cosmetic, agronomic, and pharmaceutical industries also are considered. This is the first review to consider naturally occurring neo fatty (carboxylic) acids, neo alkanes, and other metabolites containing a tertiary butyl group(s) [or tert-butyl unit(s)].

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Abbreviations

6FP:

6-formylpterin

CDH:

choline dehydrogenase

DC-A:

discodermin A

EC50 :

concentration having an effect on 50% of the population

LC50 :

concentration having a lethal effect on 50% of the population

PAF:

platelet-activating factor

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  1. Dept. of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, P.O. Box 12065, 91120, Jerusalem, Israel

    Valery M. Dembitsky

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  1. Valery M. Dembitsky
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Dembitsky, V.M. Natural neo acids and neo alkanes: Their analogs and derivatives. Lipids 41, 309–340 (2006). https://doi.org/10.1007/s11745-006-5103-9

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  • DOI: https://doi.org/10.1007/s11745-006-5103-9

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