Abstract
A 42-year-old renal transplant recipient was admitted with fever, anorexia, malaise, nonproductive cough, and dyspnea of 1-week duration. Multiple cultures of blood, sputum, and urine were negative. The possibility of bronchiolitis obliterans with organizing pneumonia (BOOP) was considered when pulmonary infiltrate did not respond to conventional antibiotic therapy. High-resolution computed tomography of the chest revealed patchy air-space consolidation and ground-glass opacities, predominantly located in the periphery of the lungs. Cultures and stains of bronchoalveolar lavage specimen and bronchoscopic biopsy of lung tissue were negative for organisms such as Pneumocystis (carinii) jiroveci, bacteria, Mycobacterium tuberculosis, cytomegalovirus, fungi, and atypical germs, and showed evidence of BOOP. The patient recovered completely after treatment with steroids.
References
Jha V (2010) Post-transplant infections: an ounce of prevention. Indian J Nephrol 20:171–178
Kalra V, Agarwal SK, Khilnani GC, Kapil A, Dar L, Singh UB et al (2005) Spectrum of pulmonary infections in renal transplant recipients in the tropics: a single center study. Int Urol Nephrol 37:551–559
Dharnidharka VR, Stablein DM, Harmon WE (2004) Post-transplant infections now exceed acute rejection as cause for hospitalization: a report of the NAPRTCS. Am J Transplant 4:384–389
White KA, Ruth-Sahd LA (2007) Bronchiolitis obliterans organizing pneumonia. Crit Care Nurse 27:53–66; quiz 67
Verberckmoes R, Verbeken E, Verschakelen J, Vanrenterghem Y (1996) BOOP (bronchiolitis obliterans organizing pneumonia) after renal transplantation. Nephrol Dial Transplant 11:1862–1863
Cunha BA, Syed U, Mickail N (2011) Renal transplant with bronchiolitis obliterans organizing pneumonia (BOOP) attributable to tacrolimus and herpes simplex virus (HSV) pneumonia. Heart Lung Oct 11. [Epub ahead of print]
Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H et al (2006) Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 144:505–509
Carreño CA, Gadea M (2007) Case report of a kidney transplant recipient converted to everolimus due to malignancy: resolution of bronchiolitis obliterans organizing pneumonia without everolimus discontinuation. Transplant Proc 39:594–595
Bitzan M, Ouahed JD, Carpineta L, Bernard C, Bell LE (2010) Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease. Pediatr Nephrol 25:1163–1167 (Epub 2010 Feb 6)
Epler GR, Colby TV, McLoud TC, Carrington CB, Gaensler EA (1985) Bronchiolitis obliterans organizing pneumonia. N Engl J Med 312:152–158
Chapman JR, O’Connell PJ, Nankivell BJ (2005) Chronic renal allograft dysfunction. J Am Soc Nephrol 16(10):3015–3026 (Epub 2005 Aug 24)
Kadambi PV, Murphy B, Sheridan AM Differential diagnosis of renal allograft dysfunction. http://www.uptodate.com. [topic last updated: Feb 11, 2011, Literature review current through: Jan 2012]
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Kute, V.B., Patel, M.P., Patil, S.B. et al. Bronchiolitis obliterans organizing pneumonia (BOOP) after renal transplantation. Int Urol Nephrol 45, 1517–1521 (2013). https://doi.org/10.1007/s11255-012-0182-4
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DOI: https://doi.org/10.1007/s11255-012-0182-4