Abstract
The Keggin type polyoxotungstate [Ti2W10PO40]7− forms stable associates with the biopolymer chitosan in the nanometer size range. The cluster compound crystallizes from aqueous solution as K4H3[Ti2W10PO40] · 15H2O having a tetragonal structure. Both, the cluster compound and the chitosan/[Ti2W10PO40] associates show a high hydrolytic stability at pH 7.4. The associates formed between the cluster anion [Ti2W10PO40]7− with the polyaminosaccharide chitosan have been characterized by photon correlation spectroscopy, scanning electron microscopy, filtration, centrifugation and zeta potential measurements. The size of the associates formed is in the range of ca. 5×101 to 5×102 nm. These particles have a defined stoichiometry with 5–6 cluster anions bound per molecule chitosan. The isoelectric point determined by zeta potential measurements was found for a cluster anion to chitosan molar ratio of 5.5, indicating the charge neutralization between protonated chitosan and [Ti2W10PO40]7− anions. Cellular uptake studies with [Ti2W10PO40]7− using tumor cell lines FaDu (human squamous carcinoma) and HT-29 (human adenocarcinoma) showed that the tungsten amount inside the cells is remarkably enhanced in the presence of chitosan.
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References
M.T. Pope (1983) Heteropoly and Isopoly Oxometalates Springer Verlag Berlin
M.T. Pope A. Müller (Eds) (2001) Polyoxometalate Chemistry: From Topology via Self-Assembly to Applications Kluwer Academic Publishers Dordrecht/Boston, London
J.T. Rhule C.L. Hill D.A. Judd R.F. Schinazi (1998) Chem. Rev. 98 327 Occurrence Handle1:CAS:528:DyaK1cXotVShtQ%3D%3D Occurrence Handle10.1021/cr960396q
U. Kortz J. Vaissermann R. Thouvenot P. Gouzerh (2003) Inorg. Chem. 42 1135 Occurrence Handle1:CAS:528:DC%2BD3sXjvFGmug%3D%3D Occurrence Handle10.1021/ic0261427
J. Li Y. Qi J. Li H. Wang X. Wu L. Duan E. Wang (2004) ArticleTitleHeteropolymolybdate-amino acid complexes: Synthesis, characterization and biological activity Journal of Coordination Chemistry 57 1309 Occurrence Handle1:CAS:528:DC%2BD2cXpsFaguro%3D Occurrence Handle10.1080/00958970412331295237
D.G. Kurth, P. Lehmann, D. Volkmer, A. Müller and D. Schwahn, J. Chem. Soc. Dalton Trans., 3989 (2000)
D. Volkmer A. Du Chesne D.G. Kurth H. Schnablegger P. Lehmann M.J. Koop A. Müller (2000) J. Am. Chem. Soc. 122 1995 Occurrence Handle1:CAS:528:DC%2BD3cXhtFykurg%3D Occurrence Handle10.1021/ja992350v
D. Volkmer B. Bredenkotter J. Tellenbroker P. Kogerler D.G. Kurth P. Lehmann H. Schnablegger D. Schwahn M. Piepenbrink B. Krebs (2002) J. Am. Chem. Soc. 124 10489 Occurrence Handle1:CAS:528:DC%2BD38XmtVCnt78%3D Occurrence Handle10.1021/ja017613b
X.H. Wang, J.F. Liu and M.T. Pope, J. Chem. Soc. Dalton Trans., 957 (2003)
Y. Yang J. He X. Wang B. Li J. Liu (2004) Transition Met. Chem. 29 96 Occurrence Handle1:CAS:528:DC%2BD2cXovVCksQ%3D%3D Occurrence Handle10.1023/B:TMCH.0000014494.72867.c5
X.H. Wang L.L. Xu Y.W. Li F. Li (2005) J. Nanosci. Nanotechnol. 5 905 Occurrence Handle1:CAS:528:DC%2BD2MXltVamsb8%3D Occurrence Handle10.1166/jnn.2005.145
X.H. Wang F. Li S.X. Liu M.T. Pope (2005) J. Inorg. Biochem. 99 452 Occurrence Handle1:CAS:528:DC%2BD2cXhtFGhsLjF Occurrence Handle10.1016/j.jinorgbio.2004.10.020
Y.V. Mironov, M.A. Shestopalov, K.A. Brylev, S.S. Yarovoi, G.V. Romanenko, V.E. Fedorov, H. Spies, H.-J. Pietzsch, H. Stephan, G. Geipel, G. Bernhard and W. Kraus, Eur. J. Inorg. Chem., 657 (2005)
Y.V. Mironov K.A. Brylev M.A. Shestopalov S.S. Yarovoi V.E. Fedorov H. Spies H.-J. Pietzsch H. Stephan G. Geipel G. Bernhard W. Kraus (2006) Inorg. Chim. Acta 359 1129 Occurrence Handle1:CAS:528:DC%2BD28Xhs1Smsrs%3D Occurrence Handle10.1016/j.ica.2005.08.012
P.J. Domaille W.H. Knoth (1983) Inorg. Chem. 22 818 Occurrence Handle1:CAS:528:DyaL3sXhtVSis7w%3D Occurrence Handle10.1021/ic00147a023
G.M. Sheldrick (1997) SHELXS-97, Program for the Solution of Crystal Structures University of Gottingen Germany
G.M. Sheldrick (1997) SHELXL-97, Program for the Crystal Structure Refinement University of Gottingen Germany
J.F. Keggin (1934) Proc. Roy. Soc. London A 144 75
W. Provencher (1982) Comput. Phys. Commun. 27 213 Occurrence Handle10.1016/0010-4655(82)90173-4
P. Schurtenberger and M.E. Newman, in J. Buffle and H.P. van Leeuwen (eds), Environmental Particles, Boca Raton, 1993, Vol. 2, p. 37
M. Plaschke T. Schäfer T. Bundschuh T. Ngo Manh R. Knopp H. Geckeis J.I. Kim (2001) Anal. Chem. 73 4338 Occurrence Handle1:CAS:528:DC%2BD3MXlsFygsro%3D Occurrence Handle10.1021/ac010116t
P. McFadyen D. Fairhurst (1993) Clay Minerals 28 531 Occurrence Handle1:CAS:528:DyaK2cXisVymsLk%3D
H. Zänker, Analytical centrifugation with preparative centrifuges, in Report FZR-400, Annual Report of Institute of Radiochemistry, Forschungszentrum Rossendorf, 2004, p. 48
Y. Inouye Y. Tokutake J. Kunihara T. Yoshida T. Yamase A. Nakata S. Nakamura (1992) Chem. Pharm. Bull. 40 805 Occurrence Handle1:CAS:528:DyaK38XksVCgur0%3D
Y. Inouye Y. Fujimoto M. Sugiyama T. Yoshida T. Yamase (1995) Biol. Pharm. Bull. 18 996 Occurrence Handle1:CAS:528:DyaK2MXnslertrY%3D
D.L. Barnard C.L. Hill T. Gage J.E. Matheson J.H. Huffman R.W. Sidwell M.I. Otto R.F. Schinazi (1997) Antiviral Res. 34 27 Occurrence Handle1:CAS:528:DyaK2sXisFOru7s%3D Occurrence Handle10.1016/S0166-3542(96)01019-4
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Meißner, T., Bergmann, R., Oswald, J. et al. Chitosan-encapsulated Keggin Anion [Ti2W10PO40]7−. Synthesis, Characterization and Cellular Uptake Studies. Transition Met Chem 31, 603–610 (2006). https://doi.org/10.1007/s11243-006-0035-z
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DOI: https://doi.org/10.1007/s11243-006-0035-z