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Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures

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Abstract

The ion-exchange behavior of 68Ga in mixed HCl–ethanol media on cation and anion exchangers was studied. The mass distribution coefficients of 68Ga on Dowex 50 W × 8 and Dowex 1 × 8 ion-exchange resins at HCl concentrations in the range 0.1–3.0 M and with ethanol volume fractions 0–90 % were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl–ethanol solutions were studied. A process, based on the data obtained, was developed for preparing of 68Ga solutions in 0.1 M HCl with high chemical and radiochemical purity that are suitable for producing of 68Ga-radiopharmaceuticals with required quality for clinical use. The suitability of the process for the synthesis of different 68Ga-radiopharmaceuticals in routine clinical practice was demonstrated.

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Authors and Affiliations

  1. Burnasyan Federal Medical Biophysical Center, Zhivopisnaya str., bld. 46, 123182, Moscow, Russia

    A. A. Larenkov, A. B. Bruskin & G. E. Kodina

Authors
  1. A. A. Larenkov
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  2. A. B. Bruskin
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  3. G. E. Kodina
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Correspondence to A. A. Larenkov.

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Larenkov, A.A., Bruskin, A.B. & Kodina, G.E. Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures. J Radioanal Nucl Chem 305, 147–160 (2015). https://doi.org/10.1007/s10967-015-4089-2

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  • DOI: https://doi.org/10.1007/s10967-015-4089-2

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