Studies have been conducted of the reactions of 7-phenyl-3,7-dihydro-4H-pyrazolo[3,4-d]-[1,2,3]triazin-4-one with alkyl halides and formaldehyde, that occurred with retention of the pyrazolotriazine structure. Ethyl 2-(4-oxo-7-phenyl-4,7-dihydro-3H-pyrazolo[3,4-d][1,2,3]triazin-3-yl)-acetate was prepared by the reaction of 7-phenyl-3,7-dihydro-4H-pyrazolo[3,4-d][1,2,3]triazin-4-one with ethyl chloroacetate. It was used to synthesize the corresponding hydrazide with the aim of introducing the pyrazole or 1,3,4-oxadiazole fragments in the side chain of a bicyclic system.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 577-585, April, 2014.
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Gurenko, A.O., Khutova, B.M., Klyuchko, S.V. et al. Synthesis of Novel Pyrazolo[3,4-d][1,2,3]Triazines. Chem Heterocycl Comp 50, 528–536 (2014). https://doi.org/10.1007/s10593-014-1503-6
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DOI: https://doi.org/10.1007/s10593-014-1503-6