Abstract
The effects of human mesenchymal stem cells on neurological functions and behavioral reactions of animals and on damaged brain tissue were studied on the model of focal cerebral ischemia in rats. Homing and differentiation of transplanted mesenchymal stem cells were also studied. Significant regression of neurological disorders after cell transplantation was noted, no appreciable shifts were detected by magnetic resonance tomography. Homing of transplanted cells was detected mainly in the zone of focal ischemia. Some cells died, others exhibited signs of differentiation into neurons and glia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. B. Vladimirskaya, O. A. Maiorova, S. A. Rumyantsev, and A. G. Rumyantsev, Biological Bases and Prospects of Stem Cell Therapy [in Russian], Moscow (2005), pp. 278–290.
A. A. Kamenskii and K. V. Savelyeva, Nitrogen Oxide and Behavior [in Russian], Moscow (2002), pp. 59–71.
Yu. G. Suzdal’tseva, V. V. Burunova, and N. V. Pertrakova, Kletoch. Tekhnol. Biol. Med., No. 1, 3–10 (2007).
V. N. Yarygin and K. N. Yarygin, Problems in Morphology and Pathology [in Russian], Moscow (2007), pp. 28–69.
C. V. Borlongan and D. Hess, CMAJ, 174, No. 7, 954–955 (2006).
C. V. Borlongan, H. Hida, H. Nishino, et al., Neuroreport, 16, No. 9, 3615–3621 (1998).
J. Chen, Y. Li, M. Katakowski, et al., J. Neurosci. Res., 73, No. 6, 778–786 (2003).
Y. Li, J. Chen, X. G. Chen, et al., Neurology, 59, No. 4, 514–523 (2002).
D. Kondziolka, L. Wechsler, J. Gebel, et al., Phys. Med. Rehab. Clin. N. Am., 14, Suppl. 1, S153–S166 (2003).
A. E. Willing, J. Lixian, and M. Milliken, Neurosci. Res., 73, No. 3, 296–307 (2003).
R. Ukai, O. Honmon, K. Harada, et al., J. Neurotrauma, 24, No. 3, 508–520 (2007).
M. Vendrame, J. Cassady, J. Newcomb, et al., Stroke, 35, No. 10, 2390–2395 (2004).
A. E. Willing, M. Vendrame, J. Mallery, et al., Cell Transplant., 12, No. 4, 449–454 (2003).
Y. Zhang, C. D. Li, X. X. Jiang, et al., Chin. Med. J., 117, No. 6, 882–887 (2004).
Author information
Authors and Affiliations
Additional information
__________
Translated from Kletochnye Tehnologii v Biologii i Meditsine, No. 1, pp. 14–20, January, 2007
Rights and permissions
About this article
Cite this article
Skvortsova, V.I., Gubskiy, L.V., Tairova, R.T. et al. Use of bone marrow mesenchymal (stromal) stem cells in experimental ischemic stroke in rats. Bull Exp Biol Med 145, 122–128 (2008). https://doi.org/10.1007/s10517-008-0032-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-008-0032-7