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Heterogeneous Airway Versus Tissue Mechanics and Their Relation to Gas Exchange Function During Mechanical Ventilation

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Abstract

We have advanced a commercially available ventilator (NPB840, Puritan Bennett/Tyco Healthcare, Pleasanton, CA) to deliver an Enhanced Ventilation Waveform (EVW). This EVW delivers a broadband waveform that contains discrete frequencies blended to provide a tidal breath, followed by passive exhalation. The EVW allows breath-by-breath estimates of frequency dependence of lung and total respiratory resistance (R) and elastance (E) from 0.2 to 8 Hz. We hypothesized that the EVW approach could provide continuous ventilation simultaneously with an advanced evaluation of mechanical heterogeneities under heterogeneous airway and tissue disease conditions. We applied the EVW in five sheep before and after a bronchial challenge and an oleic acid (OA) acute lung injury model. In all sheep, the EVW maintained gas exchange during and after bronchoconstriction, as well as during OA injury. Data revealed a range of disease conditions from mild to severe with heterogeneities and airway closures. Correlations were found between the arterial partial pressure of oxygen (PaO2) and the levels and frequency-dependent features of R and E that are indicative of mechanical heterogeneity and tissue disease. Lumped parameter models provided additional insight on heterogeneous airway and tissue disease. In summary, information obtained from EVW analysis can provide enhanced guidance on the efficiency of ventilator settings and on patient status during mechanical ventilation.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Boston University, Boston, Massachusetts

    C. L. Bellardine, B. Suki & K. R. Lutchen PhD

  2. Pulmonary Division, Brigham and Women’s Hospital, Boston, Massachusetts

    E. P. Ingenito

  3. Tufts University School of Veterinary Medicine, N. Grafton, Massachusetts

    A. Hoffman

  4. Puritan Bennett/Tyco Healthcare, Pleasanton, California

    F. Lopez & W. Sanborn

  5. Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts, 02215

    K. R. Lutchen PhD

Authors
  1. C. L. Bellardine
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  2. E. P. Ingenito
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  3. A. Hoffman
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  4. F. Lopez
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  5. W. Sanborn
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  6. B. Suki
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  7. K. R. Lutchen PhD
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Correspondence to K. R. Lutchen PhD.

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Bellardine, C.L., Ingenito, E.P., Hoffman, A. et al. Heterogeneous Airway Versus Tissue Mechanics and Their Relation to Gas Exchange Function During Mechanical Ventilation. Ann Biomed Eng 33, 626–641 (2005). https://doi.org/10.1007/s10439-005-1540-5

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  • DOI: https://doi.org/10.1007/s10439-005-1540-5

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