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Effect of functionalized multi-walled carbon nanotubes with poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the release of tramadol hydrochloride

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Abstract

Multi-walled carbon nanotubes (MWCNTs) were grafted with poly(N-vinyl-2-pyrrolidone) and with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) at different compositions by using γ-rays technique as initiator. The MWCNTs, MWCNT-graft-PNVP, MWCNT-graft-PAMPS and MWCNTs-graft-P(NVP-co-AMPS) were characterized by Fourier transform infra red (FTIR) spectroscopy, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), elemental analysis and high-resolution transmission electron microscopy (HR-TEM). The results indicated that the grafting processes of PNVP, PAMPS and P(NVP-co-AMPS) occurred on to the surfaces of MWCNTs without destroying the framework of MWCNTs. Tramadol hydrochloride (TH) was loaded as model drug and its release behavior was analyzed via various kinetic models. Release of the loaded TH was studied in simulated gastric fluid (SGF, pH = 1.2) and simulated intestinal fluid (SIF, pH = 7.4) at 37 °C. Controlled release of TH from grafted MWCNTs was investigated. The outcome results suggest that the grafted MWCNTs could be used as a promising matrix candidate for oral drug delivery system by harmonization between the composition and pH level of the simulated biological fluids.

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References

  1. Tasis, D., Tagmatarchis, N., Bianco, A. and Prato, M., Chem. Rev., 2006, 106(3): 1105

    Article  CAS  Google Scholar 

  2. Moniruzzaman, M. and Winey, K.I., Macromolecules, 2006, 39(16): 5194

    Article  CAS  Google Scholar 

  3. Coleman, J.N., Khan U., Blau, W.J. and Gun’ko, Y.K., Carbon, 2006, 44(9): 1624

    Article  CAS  Google Scholar 

  4. Paradise, M. and Goswami, T., Mater. Design, 2007, 28(5): 1477

    Article  CAS  Google Scholar 

  5. Hanzel, O., Sedláček, J. and Šajgalík, P., J. Eur. Ceram. Soc., 2014, 34(7): 1845

    Article  CAS  Google Scholar 

  6. Huang, W., Lin, Y., Taylor, S., Gaillard, J., Rao, A.M. and Sun, Y.P., Nano Lett., 2002, 2(3): 231

    Article  CAS  Google Scholar 

  7. Jin, J., Li, R., Wang, H., Chen, H., Liang, K. and Ma, J., Chem. Commun., 2007, 4(4): 386

    Article  Google Scholar 

  8. Tasis, D., Papagelis, D., Prato, M., Kallitsis, I. and Galiotis, C., Macromol. Rapid Commun., 2007, 28(15): 1553

    Article  CAS  Google Scholar 

  9. Hong, C.Y., You, Y.Z. and Pan, C.Y., Chem. Mater., 2005, 17(19): 2247

    Article  CAS  Google Scholar 

  10. Zhang, H., Li, H.X. and Cheng, H.M., J. Phys. Chem. B, 2006, 110(18): 9095

    Article  CAS  Google Scholar 

  11. Wang, T., Zhao, G.C. and Wei, X.W., Chem. Lett., 2005, 34(4): 518

    Article  Google Scholar 

  12. Pei, X., Hu, L., Liu, W. and Hao, J., Eur. Polym. J., 2008, 44(12): 2458

    Article  CAS  Google Scholar 

  13. Lebitasy, M., Hecq, J.D., Vanbeckbergen, D., Jamart, J. and Galanti, L., Ann. Pharm. Fran., 2009, 67(4): 272

    Article  CAS  Google Scholar 

  14. Obaidat, A.A. and Obaidat, R.M., Eur. J. Pharm. Biopharm., 2001, 52(2): 231

    Article  CAS  Google Scholar 

  15. Tan, X.L., Fang, M., Chen, C.L., Yu, S.M. and Wang, X.K., Carbon, 2008, 46(13): 1741

    Article  CAS  Google Scholar 

  16. Xie, X., Gao, L. and Sun, J., Colloids Surf. A, 2007, 308(1–3): 54

    Article  CAS  Google Scholar 

  17. Chang, P.R., Zheng, P.W., Liu, B.X., Anderson, D.P., Yu, J.G. and Ma, X.F., J. Hazard. Mater., 2011, 186(2–3): 2144

    Article  CAS  Google Scholar 

  18. Mishra, A.K. and Ramaprabhu, S., J. Phys. Chem. C, 2010, 114(6): 2583

    Article  CAS  Google Scholar 

  19. Jia, B.P. and Gao, L., J. Phys. Chem. B, 2007, 111(19): 5337

    Article  CAS  Google Scholar 

  20. Kong, L.R., Lu, X.F. and Zhang, W.J., J. Solid State Chem., 2008, 181(3): 628

    Article  CAS  Google Scholar 

  21. Zhao, L., Xu, L, Mitomo, H. and Yoshii, F., Carbohydr. Polym., 2006, 64(3): 473

    Article  CAS  Google Scholar 

  22. Bozkurt, A., Ekinci, O. and Meyer, W.H., J. Appl. Polym. Sci., 2003, 90(12): 3347

    Article  CAS  Google Scholar 

  23. Rosa, F., Bordado, J. and Casquilho, M., J. Appl. Polym. Sci., 2003, 87(2): 192

    Article  CAS  Google Scholar 

  24. Travas-Sejdic, J. and Easteal, A., J. Appl. Polym. Sci., 2000, 75(5): 619

    Article  CAS  Google Scholar 

  25. Rivas, B.L., Pooley, S.A., Luna, M. and Geckeler, K.E., J. Appl. Polym. Sci., 2001, 82(1): 22

    Article  CAS  Google Scholar 

  26. Peng, J., Qu, X.X., Wei, G.S., Li, J.Q. and Qiao, J.L., Carbon, 2004, 42(47): 2741

    Article  CAS  Google Scholar 

  27. Jiang, B. and Huang, G., Radiat. Phys. Chem., 2004, 69(11): 433

    Article  CAS  Google Scholar 

  28. Hong, K., Liu, N. and Sun, S., Eur. Polym. J., 2009, 45(8): 2443

    Article  CAS  Google Scholar 

  29. Shao, D., Jiang, Z., Wang, X., Li, J. and Meng, Y., J. Phys. Chem. B, 2009, 113(4): 860

    Article  CAS  Google Scholar 

  30. Saini, R.K., Chiang, I.W., Peng, H., Smalley, R.E., Billups, W.E., Hauge, R.H. and Margrave, J.L., J. Am. Chem. Soc., 2003, 125(12): 3617

    Article  CAS  Google Scholar 

  31. Brophy, M.R. and Deasy, P.B., Int. J. Pharm., 1987, 37(14): 41

    Article  CAS  Google Scholar 

  32. Ritger, P.L. and Peppas, N.A., J. Control. Release, 1987, 5(1): 37

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. National Center for Radiation Research and Technology, P.O. Box 29, Nasr City, Cairo, Egypt

    Ahmed Awadallah-F

  2. Chemistry Department, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt

    Tahia B. Mostafa

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  1. Ahmed Awadallah-F
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  2. Tahia B. Mostafa
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Correspondence to Ahmed Awadallah-F.

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Awadallah-F, A., Mostafa, T.B. Effect of functionalized multi-walled carbon nanotubes with poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the release of tramadol hydrochloride. Chin J Polym Sci 33, 376–385 (2015). https://doi.org/10.1007/s10118-015-1591-5

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  • DOI: https://doi.org/10.1007/s10118-015-1591-5

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