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Antiangiogenic therapy of brain tumors: the role of bevacizumab

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Abstract

Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.

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Authors and Affiliations

  1. Division of Neuro-Oncology, Department of Neuroscience, University and AO Città della Salute e della Scienza, Via Cherasco, 15, 10126, Turin, Italy

    Elisa Trevisan, Luca Bertero, Chiara Bosa, Michela Magistrello, Alessia Pellerino, Roberta Rudà & Riccardo Soffietti

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  1. Elisa Trevisan
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Correspondence to Elisa Trevisan.

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Trevisan, E., Bertero, L., Bosa, C. et al. Antiangiogenic therapy of brain tumors: the role of bevacizumab. Neurol Sci 35, 507–514 (2014). https://doi.org/10.1007/s10072-014-1627-6

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