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Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion

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Abstract

Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2–4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.

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Acknowledgments

This work was supported in part by a Grant for Food Safety from the Ministry of Health, Labour, and Welfare of Japan.

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Correspondence to Tomoichiro Oka.

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Iwakiri, A., Ganmyo, H., Yamamoto, S. et al. Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion. Arch Virol 154, 689–693 (2009). https://doi.org/10.1007/s00705-009-0358-0

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  • DOI: https://doi.org/10.1007/s00705-009-0358-0

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