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Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation

  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/Purpose

This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation.

Methods

Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation.

Results

Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%).

Conclusions

Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.

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Authors and Affiliations

  1. Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Toshihiko Ikegami, Yasuhiko Hashikura, Yuichi Nakazawa, Koichi Urata, Atsuyoshi Mita, Yasunari Ohno, Masaru Terada & Shin-ichi Miyagawa

  2. Department of Plastic Surgery, Shinshu University School of Medicine, Matsumoto, Japan

    Hideo Kushima & Shoji Kondoh

Authors
  1. Toshihiko Ikegami
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  2. Yasuhiko Hashikura
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  3. Yuichi Nakazawa
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  4. Koichi Urata
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  5. Atsuyoshi Mita
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  6. Yasunari Ohno
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  7. Masaru Terada
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  8. Shin-ichi Miyagawa
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  9. Hideo Kushima
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  10. Shoji Kondoh
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Cite this article

Ikegami, T., Hashikura, Y., Nakazawa, Y. et al. Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation. J Hepatobiliary Pancreat Surg 13, 105–109 (2006). https://doi.org/10.1007/s00534-005-1015-y

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  • DOI: https://doi.org/10.1007/s00534-005-1015-y

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