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Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit

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Abstract

Purpose

Hydration is needed before and after cisplatin infusion for reducing the risk of nephrotoxicity. Even though there is no standard regimen, patients receive mostly intravenous hydration before and after cisplatin leading hospitalization during at least one night. Since the feasibility has been published, oral hydration after cisplatin was implemented in our practice. The safety of this new way of hydration needs to be assessed in clinical practice.

Methods

We collected medical records from patients treated by cisplatin for lung cancer in our unit between 2010 and 2016. We retrospectively analyzed the incidence of cisplatin induced nephrotoxicity between after and before the change of hydration regimen.

Results

Our patient cohort included 241 patients hydrated by intravenous regimen (IV/IV group) and 276 patient hydrated by intravenous and oral regimen (IV/PO group). Grade ≥ 1 nephrotoxicity occurred in 39.4 and 25.7% in the IV/IV and IV/PO groups respectively (p = 0.001). Age over 70 at baseline was a predictive factor for nephrotoxicity, but not estimated glomerular filtration rate nor cisplatin-associated drugs. After a multivariate analysis, age remained a predictive factor for nephrotoxicity and IV/PO hydration associated with a decrease in nephrotoxic risk.

Conclusion

The implementation of oral hydration in our practice was not associated with an increase in nephrotoxicity. Our observation based on large data from clinical practice shows that oral hydration after cisplatin is safe.

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Authors and Affiliations

  1. Pharmacy department IUCT (Institut Universitaire du Cancer) Oncopole, Institut Claudius Regaud, Toulouse, France

    Florent Puisset, Marie Noëlle Paludetto & Audrey Martel

  2. CRCT (Cancer Research Centre of Toulouse), Université de Toulouse, Inserm UMR 1037, Université Paul Sabatier, 31059, Toulouse Cedex 9, France

    Florent Puisset & Marie Noëlle Paludetto

  3. Pharmacie, Institut Universitaire du Cancer Toulousain-Oncopole, 1 Avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France

    Florent Puisset

  4. Thoracic Oncology Department, Larrey Hospital, University Hospital Toulouse, Toulouse, France

    Laurence Bigay-Game, Audrey Rabeau & Julien Mazieres

  5. Pharmacy department IUCT (Institut Universitaire du Cancer) Oncopole, University Hospital Toulouse, Toulouse, France

    Sophie Perriat & Jean Marie Canonge

  6. Université Paul Sabatier, Toulouse, France

    Julien Mazieres

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  1. Florent Puisset
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Correspondence to Florent Puisset.

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This study was performed in the respect for ethical consideration of research involving human participant. Since it was a retrospective study based on existing data, formal consent is not required.

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The authors declare that they have no conflict of interest.

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Puisset, F., Bigay-Game, L., Paludetto, M.N. et al. Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit. Support Care Cancer 27, 1679–1686 (2019). https://doi.org/10.1007/s00520-018-4415-7

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  • DOI: https://doi.org/10.1007/s00520-018-4415-7

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