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Correlation between depth and area of retinal nerve fiber layer defect as measured by spectral domain optical coherence tomography

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To evaluate the correlation between the depth and area of retinal nerve fiber layer (RNFL) defect, as measured on an RNFL map of spectral-domain optical coherence tomography (SD-OCT).

Methods

The RNFL of 472 glaucoma subjects and of 217 healthy subjects was imaged by an SD-OCT. RNFL defect depth and area on the RNFL map were expressed as an RNFL defect depth percentage index (RDPI) and an RNFL defect area index (RDAI), respectively, according to the following two formulas: 100×[1–{summation of thicknesses of RNFL defects/summation of thicknesses of upper 95th percentile range of age-matched healthy subjects in areas corresponding to defects}]; 100×[number of superpixels of RNFL defects/(46 × 46–superpixels inside optic disc or β zone parapapillary atrophy)]. The best-fitting model describing the relationship between the two parameters was derived by fractional polynomial analysis.

Results

Logarithmic fit was determined to be the best-fitting model in describing the relationship of the RDPI against the RDAI (y = 53.4 + 3.7 ln(x) and y = 50.9 + 5.9 ln(x) in superior and inferior hemifields, respectively). The expected RDAIs at the point where the RDPI and RDAI rates of change were the same were 3.7 and 5.9 %; the corresponding upper 95 % confidence interval limits of the RDPI 59.0 and 61.8 % in the superior and inferior hemifields, respectively.

Conclusions

The correlation between the RNFL defect depth and area, as derived from the RNFL map, was best described by the logarithmic fit. Changes were more marked in depth than in area, especially for mild localized defects.

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Acknowledgments

This work was supported by a grant from Research year of Inje University in 2015.

Conflict of Interest

None of the authors has any financial/conflicting interests to disclose.

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Authors and Affiliations

  1. Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, 1435 Jwa-dong, Haeundae-gu, Busan, 612-030, Korea

    Min Hee Suh & Jung Yup Kim

  2. Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea

    Byeong Wook Yoo

  3. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

    Ki Ho Park

  4. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea

    Ki Ho Park

  5. Department of Applied Statistics, Yonsei University, Seoul, Korea

    Hyunjoong Kim

  6. Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea

    Hee Chan Kim

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  1. Min Hee Suh
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  2. Byeong Wook Yoo
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  3. Ki Ho Park
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Correspondence to Min Hee Suh.

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Suh, M.H., Yoo, B.W., Park, K.H. et al. Correlation between depth and area of retinal nerve fiber layer defect as measured by spectral domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 253, 925–934 (2015). https://doi.org/10.1007/s00417-015-2982-6

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  • DOI: https://doi.org/10.1007/s00417-015-2982-6

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