Abstract
Background
To evaluate factors affecting corneal hysteresis (CH) in normal eyes.
Methods
We examined 86 normal eyes of 43 healthy volunteers (age, 39.1 ± 14.5 years (mean ± standard deviation); range, 19 to 68 years; gender, 26 men, 60 women; manifest refraction, −2.25 ± 2.89 diopters (D); range, −9.13 to 3.88 D). We quantitatively assessed the value of CH using an Ocular Response Analyzer™ (Reichert Ophthalmic Instruments). We carried out this measurement three times, and the average value was used for statistical analysis. Multiple regression analysis was used to assess the relevant factors of the CH.
Results
The mean CH was 10.2 ± 1.3 mmHg. Explanatory variables relevant to the CH were, in order of magnitude of influence, the central corneal thickness (CCT) (partial regression coefficient B = 0.022, p < 0.0001), and the intraocular pressure (IOP) (B = -0.119, p = 0.04). No significant correlation was seen with other clinical factors such as age, gender, manifest refraction, or mean keratometric readings.
Conclusions
Eyes with thinner CCT and eyes with higher IOP are more predisposed to have lower CH. Refractive surgeons should, from a biomechanical viewpoint, take not only CCT but also IOP into consideration before performing keratorefractive surgery.
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References
Roberts C (2002) Biomechanics of the cornea and wavefront-guided laser refractive surgery. J Refract Surg 18:S589–S592
Kamiya K, Miyata K, Tokunaga T et al (2004) Structural analysis of the cornea using scanning-slit corneal topography in eyes undergoing excimer laser refractive surgery. Cornea 23:S59–S64
Jaycock PD, Lobo L, Ibrahim J et al (2005) Interferometric technique to measure biomechanical changes in the cornea induced by refractive surgery. J Cataract Refract Surg 31:175–184
Deenadayalu C, Mobasher B, Rajan SD, Hall GW (2006) Refractive change induced by the LASIK flap in a biomechanical finite element model. J Refract Surg 22:286–292
Dupps WJ Jr, Wilson SE (2006) Biomechanics and wound healing in the cornea. Exp Eye Res 83:709–720
Orssengo GJ, Pye DC (1999) Determination of the true intraocular pressure and modulus of elasticity of the human cornea in vivo. Bull Math Biol 61:551–572
Liu J, Roberts CJ (2005) Influence of corneal biomechanical properties on intraocular pressure measurement; quantitative analysis. J Cataract Refract Surg 31:146–155
Herndon LW (2006) Measuring intraocular pressure-adjustments for corneal thickness and new technologies. Curr Opin Ophthalmol 17:115–119
Bryant MR, McDonnell PJ (1996) Constitutive laws for biomechanical modeling of refractive surgery. J Biomech Eng 118:473–481
Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162
Lu F, Xu S, Qu J, Shen M, Wang X, Fang H, Wang J (2007) Central corneal thickness and corneal hysteresis during corneal swelling induced by contact lens wear with eye closure. Am J Ophthalmol 143:616–622
Lam A, Chen D, Chiu R, Chui WS (2007) Comparison of IOP measurements between ORA and GAT in normal Chinese. Optom Vis Sci 84:909–914
Broman AT, Congdon NG, Bandeen-Roche K, Quigley HA (2007) Influence of corneal structure, corneal responsiveness, and other ocular parameters on tonometric measurement of intraocular pressure. J Glaucoma 16:581–588
Shah S, Laiquzzaman M, Cunliffe I, Mantry S (2006) The use of the Reichert ocular response analyser to establish the relationship between ocular hysteresis, corneal resistance factor and central corneal thickness in normal eyes. Cont Lens Anterior Eye 29:257–262
Ortiz D, Piñero D, Shabayek MH, Arnalich-Montiel F, Alió JL (2007) Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and keratoconic eyes. J Cataract Refract Surg 33:1371–1375
Pepose JS, Feigenbaum SK, Qazi MA, Sanderson JP, Roberts CJ (2007) Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry. Am J Ophthalmol 143:39–47
Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I (2007) Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci 48:3026–3031
Kotecha A, Elsheikh A, Roberts CR, Zhu H, Garway-Heath DF (2006) Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol Vis Sci 47:5337–5347
Toshino A, Uno T, Ohashi Y et al (2005) Transient keratectasia caused by intraocular pressure elevation after laser in situ keratomileusis. J Cataract Refract Surg 31:202–204
Hiatt JA, Wachler BS, Grant C (2005) Reversal of laser in situ keratomileusis-induced ectasia with intraocular pressure reduction. J Cataract Refract Surg 31:1652–1655
Kirwan C, O’Keefe M, Lanigan B (2006) Corneal hysteresis and intraocular pressure measurement in children using the reichert ocular response analyser. Am J Ophthalmol 142:990–992
Luce D (2006) Methodology for cornea compensated IOP and corneal resistance factor for Reichert ocular response analyzer. ARVO abstract 2266. Invest Ophthalmol Vis Sci
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Kamiya, K., Hagishima, M., Fujimura, F. et al. Factors affecting corneal hysteresis in normal eyes. Graefes Arch Clin Exp Ophthalmol 246, 1491–1494 (2008). https://doi.org/10.1007/s00417-008-0864-x
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DOI: https://doi.org/10.1007/s00417-008-0864-x