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Lung Function Response to 12-week Treatment with Combined Inhalation of Long-acting β2 Agonist and Glucocorticoid According to ADRB2 Polymorphism in Patients with Chronic Obstructive Pulmonary Disease

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Abstract

Recent reports suggest that β2-adrenergic receptor (ADRB2) genotypes are associated with therapeutic responses to β2 agonists in asthmatics. However, few studies have investigated therapeutic responses to β2 agonists in chronic obstructive pulmonary disease (COPD) patients. This study investigated immediate bronchodilator response and lung function responses following a 12-week treatment with a long-acting β2 agonist combined with a steroid inhaler in patients with COPD with various ADRB2 genotypes. One hundred four patients with chronic obstruction were genotyped for codon 16 and 27 polymorphisms of the ADRB2 gene. The immediate bronchodilator response to β2-agonist treatment was evaluated after inhalation of 400 μg salbutamol. In addition, long-term response was evaluated using observed change in spirometric values before and after the treatment with salmeterol (50 μg) combined with fluticasone propionate (500 μg) inhalation twice daily for 12 weeks. In terms of codon 16 variants, the immediate bronchodilator response to salbutamol was 6.4 ± 0.8% (% predicted value) in Arg/Arg patients, 4.9 ± 0.7% in Arg/Gly patients, and 5.8 ± 1.2% in Gly/Gly patients (p = 0.418). The FEV1 changes following the 12-week treatment were 7.0 ± 1.2% in Arg/Arg patients, 3.0 ± 1.5% in Arg/Gly patients, and 7.2 ± 1.2% in Gly/Gly patients (p = 0.229). Similarly, there was no difference between codon 27 variants in terms of immediate bronchodilator response or FEV1 changes after 12 weeks of treatment. We were unable to demonstrate an association between ADRB2 genotype and the effect on lung function of 12-week treatment with combined long-acting β2 agonist and glucocorticoid inhalation or on the immediate bronchodilator response to a short-acting β2 agonist in patients with COPD.

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Acknowledgments

This study was supported by a grant (A040153) from the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea, and by the pharmaceutical companies GlaxoSmithKline Korea and AstraZeneca Korea.

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Authors and Affiliations

  1. Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, South Korea

    Woo Jin Kim

  2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Sonpa-gu, Seoul, 138-736, South Korea

    Yeon-Mok Oh & Sang Do Lee

  3. Department of Cancer Prevention and Epidemiology, National Cancer Center, Goyang, South Korea

    Joohon Sung

  4. Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, South Korea

    Tae-Hyung Kim

  5. Department of Internal Medicine, Ilsan Paik Hospital, Inje University, Goyang, South Korea

    Jin Won Huh & Hoon Jung

  6. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Seongnam, South Korea

    Ji-Hyun Lee & Eun-Kyung Kim

  7. Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea

    Jin Hwa Lee

  8. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Clinical Research Institute, Seoul National University Hospital, Lung Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea

    Sang-Min Lee

  9. Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Korea University Anam Hospital, Seoul, South Korea

    Sangyeub Lee

  10. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Seong Yong Lim

  11. Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea

    Tae Rim Shin

  12. Respiratory Center, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine, Seongnam, South Korea

    Ho Il Yoon & Sung-Youn Kwon

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  1. Woo Jin Kim
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  9. Jin Hwa Lee
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  13. Tae Rim Shin
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  15. Sung-Youn Kwon
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  16. Sang Do Lee
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Corresponding author

Correspondence to Sang Do Lee.

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Woo Jin Kim and Yeon-Mok Oh contributed equally to this work.

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Kim, W.J., Oh, YM., Sung, J. et al. Lung Function Response to 12-week Treatment with Combined Inhalation of Long-acting β2 Agonist and Glucocorticoid According to ADRB2 Polymorphism in Patients with Chronic Obstructive Pulmonary Disease. Lung 186, 381–386 (2008). https://doi.org/10.1007/s00408-008-9103-9

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  • DOI: https://doi.org/10.1007/s00408-008-9103-9

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