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Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever

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Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. The serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease. Although colchicine is effective in the majority of patients, there is no established treatment for those who are resistant or intolerant to colchicine. We herein report the efficacy of anakinra in a 52-year-old Turkish patient with FMF, secondary amyloidosis and renal transplant, who was resistant to colchicine treatment.

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Authors and Affiliations

  1. Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Capa, Istanbul, Turkey

    Nilüfer Alpay & Abdullah Şumnu

  2. Division of Nephrology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey

    Yaşar Çalışkan, Halil Yazıcı & Aydın Türkmen

  3. Division of Rheumatology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey

    Ahmet Gül

Authors
  1. Nilüfer Alpay
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  2. Abdullah Şumnu
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  3. Yaşar Çalışkan
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  4. Halil Yazıcı
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  5. Aydın Türkmen
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  6. Ahmet Gül
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Correspondence to Nilüfer Alpay.

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Alpay, N., Şumnu, A., Çalışkan, Y. et al. Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever. Rheumatol Int 32, 3277–3279 (2012). https://doi.org/10.1007/s00296-010-1474-6

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  • DOI: https://doi.org/10.1007/s00296-010-1474-6

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