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Critical review or scientific opinion paper: Arsenosugars—a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?

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Abstract

In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.

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References

  1. WHO-IARC, Arsenic in Drinking water. (http://monographs.iarc.fr/ENG/Monographs/vol84/mono84-6.pdf), 2004

  2. European Food Safety Authority (2009) EFSA J 7:1351. p 198

  3. Meharg AA, Williams PN, Adamako E, Lawgali YY, Deacon C, Villada A, Cambell CRJ, Sun G, Zhu YG, Feldmann J, Raab A, Zhao FJ, Islam R, Hossain S, Yanai J (2009) Environ Sci Technol 43:1612–1617

    Article  CAS  Google Scholar 

  4. Williams PN, Price AH, Raab A, Hossain SA, Feldmann J, Meharg AA (2005) Environ Sci Technol 39:5531–5540

    Article  CAS  Google Scholar 

  5. de la Calle MB, Linsinger T, Emteborg H, Charoud-Got J, Verbist I, IMEP-107: Total and inorganic As in rice, JRC/IRMM report EUR24314 EN (2010)

  6. Borak J, Hosgood HD (2007) Reg Toxicol Pharmacol 47:204–212

    Article  CAS  Google Scholar 

  7. Francesconi KA (2010) Pure Appl Chem 82:373–381

    Article  CAS  Google Scholar 

  8. Edmonds JS, Shibata Y, Francesconi KA, Rippingale RJ, Morita M (1997) Appl Organomet Chem 11:281–287

    Article  CAS  Google Scholar 

  9. Soeroes C, Goessler W, Francesconi KA, Schmeisser E, Raml R, Kienzl N, Kahn M, Fodor P, Kuehnelt D (2005) J Environ Monit 7:688–692

    Article  CAS  Google Scholar 

  10. Kahn M, Raml R, Schmeiser E, Vallant B, Francesconi KA, Goessler W (2005) Environ Chem 2:171–176

    Article  CAS  Google Scholar 

  11. Foster S, Maher W, Schmeisser E, Taylor A, Krikowa F, Apte S (2006) Environ Chem 3:304–315

    Article  CAS  Google Scholar 

  12. Oya-Ohta Y, Kaise T, Ochi T (1996) Mutat Res 357:123–129

    Google Scholar 

  13. Sakurai T (2002) Appl Organomet Chem 16:401–405

    Article  CAS  Google Scholar 

  14. Edmonds JS (2003) Francesconi KA in PJ Craig (Ed) Organometallic Chemistry in the Environment. Wiley, Chichester, pp 195–222

    Google Scholar 

  15. Kaise T, Watanabe S, Itoh K (1985) Chemosphere 14:1327–1332

    Article  CAS  Google Scholar 

  16. Vahter M, Marafante E, Dencker L (1983) Sci Tot Environ 30:197–211

    Article  CAS  Google Scholar 

  17. Newcombe C, Raab A, Williams PN, Deacon C, Haris PI, Meharg AA, Feldmann J (2010) J Environ Monit 12:832–837

    Article  CAS  Google Scholar 

  18. Raab A, Feldmann J (2005) Anal Bioanal Chem 381:332–338

    Article  CAS  Google Scholar 

  19. Yanez J, Fierro V, Mansilla H, Figueroa L, Cornejo L, Barnes RM (2005) J Environ Monit 7:1335–1341

    Article  CAS  Google Scholar 

  20. Laberke PJ, Briellmann T, Wittig H, Hausmann R (2009) Rechtsmedizin 19:231–234

    Article  Google Scholar 

  21. Kaise T, Fukui S (1992) Appl Organomet Chem 6:155–169

    Article  CAS  Google Scholar 

  22. Gamble BM, Gallagher PA, Shoemaker JA, Wei X, Schwegel CA, Creed JT (2002) Analyst 127:781–785

    Article  CAS  Google Scholar 

  23. Francesconi KA, Tanggaard R, McKenzie CJ, Goessler W (2002) Clin Chem 48:92–101

    CAS  Google Scholar 

  24. van Hulle M, Zhang C, Schotte B, Mees L, Vanhaecke F, Vanholder R, Zhang XR, Cornelis R (2004) J Anal At Spectrom 19:58–64

    Article  Google Scholar 

  25. Le XC, Cullen WR, Reimer KJ (1994) Clin Chem 40:617–624

    CAS  Google Scholar 

  26. Raml R, Raber G, Rumpler A, Bauernhofer T, Goessler W, Francesconi KA (2009) Chem Res Toxicol 22:1534–1540

    Article  CAS  Google Scholar 

  27. Vega L, Styblo M, Patterson R, Cullen W, Wang CQ, Germolec D (2001) Toxicol Appl Pharmacol 172:225–232

    Article  CAS  Google Scholar 

  28. Hansen HR, Pickford R, Thomas-Oates J, Jaspars M, Feldmann J (2004) Angew Ch Int Ed 43:337–340

    Article  CAS  Google Scholar 

  29. Hansen HR, Raab A, Jaspars M, Milne BF, Feldmann J (2004) Chem Res Toxicol 17:1086–1091

    Article  CAS  Google Scholar 

  30. Raml R, Rumpler A, Goessler W, Vahter M, Li L, Ochi T, Francesconi KA (2008) Toxicol Appl Pharmacol 222:374–380

    Article  Google Scholar 

  31. Salim EI, Wanibuchi H, Morimura K, Wei M, Mitsuhashi M, Yoshida K, Endo G, Fukushima S (2003) Carcinogenesis 24:335–342

    Article  CAS  Google Scholar 

  32. Ochi T, Kita K, Suzuki T, Rumpler A, Goessler W, Francesconi KA (2008) Toxicol Appl Pharmacol 228:59–67

    Article  CAS  Google Scholar 

  33. Andrewes P, Demarini DM, Funasaka K, Wallace K, Lai VWM, Sun HS, Cullen WR, Kitchin KT (2004) Environ Sci Technol 38:4140–4148

    Article  CAS  Google Scholar 

  34. Raab A, Wright S, Jaspars M, Meharg A, Feldmann J (2007) Angew Ch Int Ed 46:2594–2597

    Article  CAS  Google Scholar 

  35. Hansen HR, Raab A, Francesconi KA, Feldmann J (2003) Environ Sci Technol 37:845–851

    Article  CAS  Google Scholar 

  36. Hansen HR, Raab A, Feldmann J (2003) J Anal At Spectrom 18:474–479

    Article  CAS  Google Scholar 

  37. Martin SJ, Newcombe C, Raab A, Feldmann J (2005) Environ Chem 2:190–197

    Article  CAS  Google Scholar 

  38. Beresford NA, Crout NMJ, Mayes RW (2001) J Agric Sci 136:331–344

    Article  CAS  Google Scholar 

  39. Feldmann J, John K, Pengprecha P (2000) Fresenius J Anal Chem 368:116–121

    Article  CAS  Google Scholar 

  40. Raab A, Hansen HR, Zhuang L, Feldmann J (2003) Talanta 58:67–76

    Article  Google Scholar 

  41. Caumette G, Ouypornkochagorn S, Scrimgeour CM, Raab A, Feldmann J (2007) Environ Sci Technol 41:2673–2679

    Article  CAS  Google Scholar 

  42. Vahter M (2009) Ann Rev Nutr 29:381–399

    Article  CAS  Google Scholar 

  43. Niegel C, Matysik FM (2010) Anal Chim Acta 657:83–99

    Article  CAS  Google Scholar 

  44. Raab A, Fecher P, Feldmann J (2005) Microchim Acta 151:153–166

    Article  CAS  Google Scholar 

  45. Leermakers M, Baeyens W, de Gieter M, Smedts B, Meert C, de Bisschop HC, Morabito R, Quevauviller PH (2006) Trends Anal Chem 25:1–10

    Article  CAS  Google Scholar 

  46. Arroyo-Abad U, Mattusch J, Mothes S, Moeder M, Wennrich R, Elizalde-Gonzalez MP, Matysik FM (2010) Talanta 82:38–43

    Article  CAS  Google Scholar 

  47. Taleshi MS, Edmonds JS, Goessler W, Ruiz-Chancho MJ, Raber G, Jensen KB, Francesconi KA (2010) Environ Sci Technol 44:1478–1483

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. TESLA Trace Element Speciation Laboratory, University of Aberdeen, Aberdeen, AB24 3UE, Scotland, UK

    Jörg Feldmann & Eva M. Krupp

  2. ACES Aberdeen Centre for Environmental Sustainability, University of Aberdeen, Aberdeen, AB24 3UU, Scotland, UK

    Eva M. Krupp

Authors
  1. Jörg Feldmann
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  2. Eva M. Krupp
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Correspondence to Jörg Feldmann.

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Published in the special issue Speciation Analysis in Healthcare with Guest Editor Heidi Goenaga Infante.

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Feldmann, J., Krupp, E.M. Critical review or scientific opinion paper: Arsenosugars—a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?. Anal Bioanal Chem 399, 1735–1741 (2011). https://doi.org/10.1007/s00216-010-4303-6

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  • DOI: https://doi.org/10.1007/s00216-010-4303-6

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