Abstract
A collection of structurally complex and chemically diverse small molecules is a useful tool to explore cell circuitry. In this article, we have reported the two step synthesis of diverse spirooxindoles. The key reaction to assemble the spirooxindole core is a Lewis acid catalyzed three component coupling. The final library of compounds was then analyzed for their cytotoxic activity against U87 human glioma cells. It is noteworthy to mention that this is the first report on the pharmaceutical evaluation of such compounds. Although the activity is moderate, it opens the door for new chemical modifications of spirooxindoles.
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Author (A. Jain) is thankful to UGC for providing senior research fellowship. M. Kidwai is grateful to the University of Delhi for providing financial assistance.
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Kidwai, M., Jain, A., Nemaysh, V. et al. Efficient entry to diversely functionalized spirooxindoles from isatin and their biological activity. Med Chem Res 22, 2717–2723 (2013). https://doi.org/10.1007/s00044-012-0249-x
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DOI: https://doi.org/10.1007/s00044-012-0249-x