Skip to main content
SpringerLink
Log in

Radioiodine is an effective, inexpensive, and safe treatment for Graves’ hyperthyroidism, but its immunological effects must be taken into account

  • Opinion
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Chiovato L., Santini F., Pinchera A. Treatment of hyperthyroidism. Thyroid International 1995, 3: 2–22.

    Google Scholar 

  2. Franklyn J.A. The management of hyperthyroidism. N. Engl. J. Med. 1994, 330: 1731–8.

    Article  CAS  PubMed  Google Scholar 

  3. Williams E.D. Biological effects of radiation on the thyroid. In Braverman L.E., Utiger R.D., Ed. Werner and Ingbar’s the Thyroid, sixth edition. Philadelphia, Lippincott Co. 1991, p. 421–36.

    Google Scholar 

  4. Heufelder A.E. Retro-orbital autoimmunity. Baillieres Clin. Endocrinol. Metabol. 1997, 11: 499–520.

    Article  CAS  Google Scholar 

  5. Feliciello A., Porcellini A., Ciullo I., Bonavolontà G., Avvedimento E.V., Fenzi G.F. Expression of thyrotropin-receptor mRNA in healthy and Graves’ disease retro-orbital tissue. Lancet 1993, 342: 337–438.

    Article  CAS  PubMed  Google Scholar 

  6. Kubota S., Gunji K., Ackrell B., Cochran B., Stolarski C., Wengrowicz S., Kennerdell J., Hiromatsu Y., Wall J. The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to eye muscle in patients with Graves’ hyperthyroidism. J. Clin. Endocrinol. Metab. 1998, 83: 443–447.

    CAS  PubMed  Google Scholar 

  7. Chiovato L., Fiore E., Vitti P., Rocchi R., Rago T., Dokic D., Latrofa F., Mammoli C., Lippi F., Ceccarelli C., Pinchera A. Outcome of thyroid function in Graves’ patients treated with radioiodine: role of thyroid stimulating and thyrotropin-blocking antibodies and of radioiodine- induced thyroid damage. J. Clin. Endocrinol. Metab. 1998, 83: 40–46.

    CAS  PubMed  Google Scholar 

  8. Pinchera A., Liberti P., Martino E., Fenzi G.F., Grasso L., Rovis L., Baschieri L. Effects of antithyroid therapy on the long-acting thyroid stimulator and the antithyroglobulin antibodies. J. Clin. Endocrinol. Metab. 1969, 29: 231–238.

    Article  CAS  PubMed  Google Scholar 

  9. DeGroot L.J. Radioiodine and the immune system. Thyroid 1997, 7: 259–264.

    Article  CAS  PubMed  Google Scholar 

  10. Chiovato L., Santini F., Vitti P., Bendinelli G., Pinchera A. Appearance of thyroid stimulating antibody and Graves’ disease after radioiodine therapy for toxic nodular goitre. Clin. Endocrinol. (Oxf.) 1994, 40: 803–806.

    Article  CAS  Google Scholar 

  11. Bartalena L., Marcocci C., Bogazzi F., Manetti L., Tanda M.L., Dell’Unto E., Bruno-Bossio G., Nardi M., Bartolomei M.P., Lepri A., Rossi G., Martino E., Pinchera A. Relation between therapy for hyperthyroidism and the course of Graves’ ophthalmopathy. N. Engl. J. Med. 1998, 338: 73–78.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Endocrinologia, Università di Pisa, via Paradisa 2, 56124, Pisa, Italy

    L. Chiovato & R. Rocchi

  2. Molecular Pathology Unit, Massachusetts General Hospital, Boston, USA

    E. Fiore

Authors
  1. L. Chiovato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Rocchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Fiore
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chiovato, L., Rocchi, R. & Fiore, E. Radioiodine is an effective, inexpensive, and safe treatment for Graves’ hyperthyroidism, but its immunological effects must be taken into account. J Endocrinol Invest 22, 310–312 (1999). https://doi.org/10.1007/BF03343562

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03343562

Key-words

Search

Navigation